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Development of a flow cytometry-based potency assay for measuring the in vitro immunomodulatory properties of mesenchymal stromal cells
(Elsevier, 2016-07-20)
Human bone marrow-derived mesenchymal stromal/stem cells (MSC) have well-documented modulatory effects on multiple immune cell types. Although these effects are linked to their therapeutic benefit in diverse diseases, a ...
Expression of RHOGTPase regulators in human myometrium
(Reproductive Biology and Endocrinology, 2008-01-11)
Background: RHOGTPases play a significant role in modulating myometrial contractility in
uterine smooth muscle. They are regulated by at least three families of proteins, RHO guanine
nucleotide exchange factors (RHOGEFs), ...
Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint
(Company of Biologists, 2016)
During mitotic arrest induced by microtubule targeting drugs, the weakening of the spindle assembly checkpoint (SAC) allows cells to progress through the cell cycle without chromosome segregation occurring. PLK1 kinase ...
Type II collagen-hyaluronan hydrogel - a step towards a scaffold for intervertebral disc tissue engineering
(European Cells & Materials Ltd, 2010-09-06)
Intervertebral disc regeneration strategies based on stem cell differentiation in combination with the design of functional scaffolds is an attractive approach towards repairing/regenerating the nucleus pulposus. The ...
A Highly Effective Gene Delivery Vector
(The Royal Society of Chemistry, 2010-06)
A hyperbranched 2-(dimethylamino)ethyl methacrylate (DMAEMA) based polymer has been synthesised by a one-pot in situ deactivation enhanced atom transfer radical polymerisation (DE-ATRP); it exhibits much higher transfection ...
Peer support for patients with type 2 diabetes: cluster randomised controlled trial
(2011-02)
Objective: To test the effectiveness of peer support for patients with type 2 diabetes.
Design: Cluster randomised controlled.
Setting: 20 general practices in the east of the Republic of Ireland.
Participants: ...
The diffusion of WOZ: expanding the topology of IS innovations
(Palgrave Macmillan, 2006-12-05)
The growth and diffusion of self-service technology (SST) over the last decade has resulted in an increasing number of business and government transactions being completed without human assistance. One innovation in this ...
International law, literature and interdisciplinarity
(Taylor & Francis, 2015-07-03)
This article analyses the relationship between international law and literature from the point of view of its form of expression. Using insights from Deleuze and Guattari's analysis of Kafka's oeuvre as a ‘minor literature’, ...
Effects of combined progesterone and 17 beta-estradiol treatment on the transcriptome of cultured human myometrial smooth muscle cells
(American Physiological Society, 2016-01-01)
A transcriptomic analysis of cultured human uterine smooth muscle cells (hUtSMCs) was performed to examine gene expression profiles in smooth muscle in an environment containing the two major steroid hormones that regulate ...
Fibrin as a scaffold for delivery of GDNF overexpressing stem cells to the adult rat brain
(2017-04-05)
Treatment of neurodegenerative disease is entering a new era where direct intracerebral delivery of therapeutic factors aims to restore normality to dysfunctional circuits. Cell-based therapeutic approaches, where virally ...