A Highly Effective Gene Delivery Vector

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Date
2010-06
Author
Newland, Ben
Tai, Hongyun
Zheng, Yu
Velasco, Diego
Di Luca, Andrea
Howdle, Steven M.
Alexander, Cameron
Wang, Wenxin
Pandit, Abhay
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Recommended Citation
Newland, B., Tai, H., Zheng, Y., Velasco, D., Di Luca, A., Howdle, S. M., et al. A highly effective gene delivery vector - hyperbranched poly(2-(dimethylamino)ethyl methacrylate) from in situ deactivation enhanced ATRP. Chemical Communications, 46(26), 4698-4700.
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Abstract
A hyperbranched 2-(dimethylamino)ethyl methacrylate (DMAEMA) based polymer has been synthesised by a one-pot in situ deactivation enhanced atom transfer radical polymerisation (DE-ATRP); it exhibits much higher transfection ability than linear poly(DMAEMA) and is comparable to the well known branched poly(ethylene imine) (PEI) and the SuperFect dendrimer but with lower cytotoxicity.
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http://hdl.handle.net/10379/1340
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Attribution-NonCommercial-NoDerivs 3.0 Ireland
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