A Highly Effective Gene Delivery Vector
Di Luca, Andrea
Howdle, Steven M.
MetadataShow full item record
This item's downloads: 741 (view details)
Newland, B., Tai, H., Zheng, Y., Velasco, D., Di Luca, A., Howdle, S. M., et al. A highly effective gene delivery vector - hyperbranched poly(2-(dimethylamino)ethyl methacrylate) from in situ deactivation enhanced ATRP. Chemical Communications, 46(26), 4698-4700.
A hyperbranched 2-(dimethylamino)ethyl methacrylate (DMAEMA) based polymer has been synthesised by a one-pot in situ deactivation enhanced atom transfer radical polymerisation (DE-ATRP); it exhibits much higher transfection ability than linear poly(DMAEMA) and is comparable to the well known branched poly(ethylene imine) (PEI) and the SuperFect dendrimer but with lower cytotoxicity.