dc.contributor.author | Krukiewicz, Katarzyna | |
dc.contributor.author | Kruk, Aleksandra | |
dc.contributor.author | Turczyn, Roman | |
dc.date.accessioned | 2019-03-14T12:39:43Z | |
dc.date.issued | 2018-09-08 | |
dc.identifier.citation | Krukiewicz, Katarzyna, Kruk, Aleksandra, & Turczyn, Roman. (2018). Evaluation of drug loading capacity and release characteristics of PEDOT/naproxen system: Effect of doping ions. Electrochimica Acta, 289, 218-227. doi: https://doi.org/10.1016/j.electacta.2018.09.011 | en_IE |
dc.identifier.issn | 0013-4686 | |
dc.identifier.uri | http://hdl.handle.net/10379/15020 | |
dc.description.abstract | Conducting polymers are versatile and robust materials that have recently become attractive as controlled drug delivery systems. Possessing ion exchangeable properties, they can serve as carriers for numerous biologically active species, showing particular applicability in neural tissue engineering and regional chemotherapy. In the pursuit of the design of the most effective controlled drug delivery system, we aimed to compare the performance of the conducting polymer-based matrix as a function of doping anion, using chloride, perchlorate and dodecyl sulfate, respectively, as the primary dopants. Due to their different ion radius and mobility, selected ions were found to provide substantial changes into polymer characteristics, having strong effects into the uptake and release of a model drug, naproxen sodium salt. PEDOT/ClO4 matrix, particularly, was found to possess superior properties providing highest mass of the formed polymer (103.45 +/- 10.09 mu g cm(-2)), charge storage capacity (44.9 mC cm(-2)) and ion exchange capacity (0.122 +/- 0.003 mu mol cm(-2)), leading also to the highest amounts of loaded (0.024 +/- 0.002 mu mol cm(-2)) and released (from 0.71 +/- 0.10 mu g cm(-2) to 1.61 +/- 0.59 mu g cm(-2)) drug. (C) 2018 Elsevier Ltd. All rights reserved. | en_IE |
dc.description.sponsorship | The authors are grateful to the National Science Centre in Poland for financing the research in the framework of Sonata (2016/23/D/ST5/01306). This publication has emanated from research conducted with the financial support of Science Foundation Ireland (SFI) and is co-funded under the European Regional Development Fund under Grant Number 13/RC/2073. This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 713690. The authors acknowledge the facilities and scientific and technical assistance of the Centre for Microscopy & Imaging at the National University of Ireland Galway, a facility that is funded by NUIG and the Irish Government's Programme for Research in Third Level Institutions, Cycles 4 and 5, National Development Plan 2007–2013. | en_IE |
dc.format | application/pdf | en_IE |
dc.language.iso | en | en_IE |
dc.publisher | Elsevier | en_IE |
dc.relation.ispartof | Electrochimica Acta | en |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Ireland | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/ie/ | |
dc.subject | ELECTROCHEMICALLY CONTROLLED-RELEASE | en_IE |
dc.subject | PEDOT CONDUCTING POLYMERS | en_IE |
dc.subject | POLY(3,4-ETHYLENEDIOXYTHIOPHENE) PEDOT | en_IE |
dc.subject | CONJUGATED POLYMERS | en_IE |
dc.subject | POLYPYRROLE FILMS | en_IE |
dc.subject | ANTIINFLAMMATORY DRUGS | en_IE |
dc.subject | NEURAL STIMULATION | en_IE |
dc.subject | POLYMERIZATION | en_IE |
dc.subject | SURFACTANT | en_IE |
dc.subject | KINETICS | en_IE |
dc.title | Evaluation of drug loading capacity and release characteristics of PEDOT/naproxen system: Effect of doping ions | en_IE |
dc.type | Article | en_IE |
dc.date.updated | 2019-03-12T12:55:22Z | |
dc.identifier.doi | 10.1016/j.electacta.2018.09.011 | |
dc.local.publishedsource | https://doi.org/10.1016/j.electacta.2018.09.011 | en_IE |
dc.description.peer-reviewed | peer-reviewed | |
dc.contributor.funder | National Science Centre in Poland | en_IE |
dc.contributor.funder | Science Foundation Ireland | en_IE |
dc.contributor.funder | European Regional Development Fund | en_IE |
dc.contributor.funder | Horizon 2020 | en_IE |
dc.description.embargo | 2020-09-08 | |
dc.internal.rssid | 16006673 | |
dc.local.contact | Manus Biggs, Nfb, Nui Galway. Email: manus.biggs@nuigalway.ie | |
dc.local.copyrightchecked | Yes | |
dc.local.version | ACCEPTED | |
dcterms.project | info:eu-repo/grantAgreement/SFI/SFI Research Centres/13/RC/2073/IE/C�RAM - Centre for Research in Medical Devices/ | en_IE |
dcterms.project | info:eu-repo/grantAgreement/EC/H2020::MSCA-COFUND-FP/713690/EU/Career Development and Mobility Fellowships in Medical Device Research and Development: A CÚRAM Industry-Academia Training Initiative./MedTrain | en_IE |
nui.item.downloads | 197 | |