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dc.contributor.authorKrukiewicz, Katarzyna
dc.contributor.authorKruk, Aleksandra
dc.contributor.authorTurczyn, Roman
dc.date.accessioned2019-03-14T12:39:43Z
dc.date.issued2018-09-08
dc.identifier.citationKrukiewicz, Katarzyna, Kruk, Aleksandra, & Turczyn, Roman. (2018). Evaluation of drug loading capacity and release characteristics of PEDOT/naproxen system: Effect of doping ions. Electrochimica Acta, 289, 218-227. doi: https://doi.org/10.1016/j.electacta.2018.09.011en_IE
dc.identifier.issn0013-4686
dc.identifier.urihttp://hdl.handle.net/10379/15020
dc.description.abstractConducting polymers are versatile and robust materials that have recently become attractive as controlled drug delivery systems. Possessing ion exchangeable properties, they can serve as carriers for numerous biologically active species, showing particular applicability in neural tissue engineering and regional chemotherapy. In the pursuit of the design of the most effective controlled drug delivery system, we aimed to compare the performance of the conducting polymer-based matrix as a function of doping anion, using chloride, perchlorate and dodecyl sulfate, respectively, as the primary dopants. Due to their different ion radius and mobility, selected ions were found to provide substantial changes into polymer characteristics, having strong effects into the uptake and release of a model drug, naproxen sodium salt. PEDOT/ClO4 matrix, particularly, was found to possess superior properties providing highest mass of the formed polymer (103.45 +/- 10.09 mu g cm(-2)), charge storage capacity (44.9 mC cm(-2)) and ion exchange capacity (0.122 +/- 0.003 mu mol cm(-2)), leading also to the highest amounts of loaded (0.024 +/- 0.002 mu mol cm(-2)) and released (from 0.71 +/- 0.10 mu g cm(-2) to 1.61 +/- 0.59 mu g cm(-2)) drug. (C) 2018 Elsevier Ltd. All rights reserved.en_IE
dc.description.sponsorshipThe authors are grateful to the National Science Centre in Poland for financing the research in the framework of Sonata (2016/23/D/ST5/01306). This publication has emanated from research conducted with the financial support of Science Foundation Ireland (SFI) and is co-funded under the European Regional Development Fund under Grant Number 13/RC/2073. This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 713690. The authors acknowledge the facilities and scientific and technical assistance of the Centre for Microscopy & Imaging at the National University of Ireland Galway, a facility that is funded by NUIG and the Irish Government's Programme for Research in Third Level Institutions, Cycles 4 and 5, National Development Plan 2007–2013.en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherElsevieren_IE
dc.relation.ispartofElectrochimica Actaen
dc.subjectELECTROCHEMICALLY CONTROLLED-RELEASEen_IE
dc.subjectPEDOT CONDUCTING POLYMERSen_IE
dc.subjectPOLY(3,4-ETHYLENEDIOXYTHIOPHENE) PEDOTen_IE
dc.subjectCONJUGATED POLYMERSen_IE
dc.subjectPOLYPYRROLE FILMSen_IE
dc.subjectANTIINFLAMMATORY DRUGSen_IE
dc.subjectNEURAL STIMULATIONen_IE
dc.subjectPOLYMERIZATIONen_IE
dc.subjectSURFACTANTen_IE
dc.subjectKINETICSen_IE
dc.titleEvaluation of drug loading capacity and release characteristics of PEDOT/naproxen system: Effect of doping ionsen_IE
dc.typeArticleen_IE
dc.date.updated2019-03-12T12:55:22Z
dc.identifier.doi10.1016/j.electacta.2018.09.011
dc.local.publishedsourcehttps://doi.org/10.1016/j.electacta.2018.09.011en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funderNational Science Centre in Polanden_IE
dc.contributor.funderScience Foundation Irelanden_IE
dc.contributor.funderEuropean Regional Development Funden_IE
dc.contributor.funderHorizon 2020en_IE
dc.description.embargo2020-09-08
dc.internal.rssid16006673
dc.local.contactManus Biggs, Nfb, Nui Galway. Email: manus.biggs@nuigalway.ie
dc.local.copyrightcheckedYes
dc.local.versionACCEPTED
dcterms.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/13/RC/2073/IE/C�RAM - Centre for Research in Medical Devices/en_IE
dcterms.projectinfo:eu-repo/grantAgreement/EC/H2020::MSCA-COFUND-FP/713690/EU/Career Development and Mobility Fellowships in Medical Device Research and Development: A CÚRAM Industry-Academia Training Initiative./MedTrainen_IE
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