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Now showing items 11-20 of 45
Investigation of the therapeutic potential of mesenchymal stem/stromal cells in preclinical models of systemic sepsis
(NUI Galway, 2020-10-29)
Introduction:
Sepsis is a syndrome of life-threatening physiologic, pathologic, and biochemical abnormalities resulting from infection 1. The host immune response, specifically the loss of immune homeostasis induced by ...
A bioinformatic approach to the genetics, human cell models and animal models of autism spectrum disorder
(NUI Galway, 2021-09-17)
Autism Spectrum Disorder (ASD) is a group of complex neurodevelopmental disorders with diverse clinical manifestations and symptoms. In the last 10 years, there have been significant advances in understanding the genetic ...
The prognostic and therapeutic value of XBP1 signalling in ER-positive breast cancer
(NUI Galway, 2021-04-02)
Breast cancer is a heterogeneous disease with distinct subtypes having specific molecular features. Approximately, 75% of breast cancers are estrogen receptor α (ER)-positive. Endocrine therapies have been used as a standard ...
The role of novel biomarkers in addressing the burden of chronic kidney disease in diabetes mellitus
(NUI Galway, 2022-10-06)
Kidney disease due to diabetes (Diabetic Kidney Disease (DKD)) is the leading cause of chronic kidney disease worldwide. It is an underappreciated, often under-recognised component of the overall burden of diabetes. People ...
Media matters: Impact of expansion media on the phenotype of mesenchymal stromal cells
(NUI Galway, 2023-03-02)
Despite a long history of investigation and sustained efforts in clinical testing with large numbers
of clinical trials being initiated, the number of market authorisations for mesenchymal stromal
cell (MSC) therapies ...
Role of gastro-oesophageal reflux in the development and severity of bronchiectasis
(NUI Galway, 2020-07-30)
Background:
Bronchiectasis is a chronic lung disease associated with significant morbidity and mortality, escalating public health costs and profound reductions in health-related quality of life (QoL). Comorbidity is a ...
Phenotypic and functional properties of HLA-DRhi intermediate monocytes in health and chronic kidney disease
(NUI Galway, 2022-03-25)
Chronic kidney disease (CKD) is a common condition, characteristed by reduced renal
function and frequently associated with progressive loss of glomerular filtration, ultimately
reaching end stage renal disease (ESRD). ...
Human stem cell modelling for heart disease of long QT syndrome
(NUI Galway, 2022-04-29)
Sudden cardiac death (SCD) in otherwise healthy young people is a public health priority. Long QT syndrome (LQTS) is the commonest life-threatening cardiac arrhythmia contributing to SCD under 40 years old with an estimated ...
Environmental and genetic risk factors in Autism Spectrum Disorder: a stereological study
(NUI Galway, 2020-07-15)
Autism spectrum disorders (ASD), include a group of heterogeneous
neurodevelopmental disorders (NDDs) characterized by impaired social interaction,
and communication with restricted patterns of behaviour. The aetiology ...
Patient involvement in measuring and monitoring patient safety in general practice
(NUI Galway, 2022-07-01)
Given their unique viewpoint at the epicentre of the care process, patients can make
a unique contribution to improving our understanding of safety in general practice.
Despite this, patients remain an underutilised ...