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Now showing items 21-30 of 114
On the oxidation of alkanes and thermodynamic properties of nitrogen-containing compounds: experimental, theoretical, and kinetic modelling studies
(2016-09-21)
The primary focus of the work presented in this Thesis involved a major re-evaluation of detailed chemical kinetic models describing alkane oxidation under combustion conditions. Combined experimental and theoretical ...
Combining biological and chemical approaches in marine biodiscovery
(2017-06-13)
Marine organisms are prolific producers of novel and structurally interesting metabolites. The identification of marine natural products contributes to many scientific areas including pharmacology, chemical ecology, chemical ...
Identification of bioactive natural products after screening Irish marine bio-resources
(2016-10-21)
According to the “Real Map of Ireland” published by Marine Institute, Ireland, the Nation marine territory has ten times more area than its land mass. Despite the well-studied and reported biodiversity present in Irish ...
First Synthesis of an Aziridinyl Fused Pyrrolo[1,2-a]benzimidazole and Cytotoxicity Evaluation of Various Imidazobenzimidazolequinones Towards Human Normal and Cancer Cell Lines
(2011-07-13)
Chapter 1 provides a review of aziridine containing anti-tumour agents and
some key syntheses of the aziridinomitosene skeleton. A novel protocol for
aziridine ring fusion is described leading to the preparation of the ...
Open-source bioelectronics for development of electrochemical biosensors and assays
(NUI Galway, 2019-02-20)
This thesis presents steps in the development of open-source bioelectronics that gather together and combine in the demonstration of a system capable of operating a fully integrated wireless electrochemical biosensor.
Synthesis of s-glycolipids and peptidomimetics
(2011-08-19)
Chapters one and two of this thesis describe the synthesis of two novel glycosphingolipid derivatives. Glycosphingolipids are amphiphilic molecules consisting of a carbohydrate head group glycosidically linked to a sphingoid ...
Development of a Chemical Kinetic Mechanism for Small Hydrocarbons
(2014-01-07)
A detailed chemical kinetic mechanism has been developed to describe the oxidation of small hydrocarbon and oxygenated hydrocarbon species. In order to understand the oxidation of large hydrocarbon and oxygenated hydrocarbon ...
Synthesis of Iminosugar C-Glycosides via Tandem Allylic Azide Rearrangement - Huisgen Cycloaddition
(2013-12-16)
Iminosugars are naturally occurring polyhydroxylated alkaloids. These natural mimics of carbohydrates have found clinical use with their biological activity mainly attributed to their inhibition of glycoprocessing enzymes. ...
Polyhedric features of cysteine: from protein functionalization to copper-binding
(2015-03-30)
This thesis comprises two main projects which are about the
cysteine chemistry involved in protein functionalization and copperbinding.
Plastocyanin functionalization via cysteine has been used to
produce a conjugate ...
Synthetic, Structural, Spectroscopic and Theoretical Studies on Homo- and Heterometallic Paramagnetic Complexes
(2013-01-08)
This thesis covers many areas within the field of molecular magnetism. With the exception of chapter 6, all novel complexes in this thesis have been synthesized using the bidentate ligand 2,2'-biphenol (LH2), usually in ...