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Now showing items 11-20 of 23
Towards an additive manufactured macroencapsulation device for islet cell replacement therapy
(NUI Galway, 2020-07-28)
Islet encapsulation devices can induce a Foreign Body Response (FBR) and the formation of a hardened avascular fibrotic capsule. This FBR is heightened when the device features a smooth surface as fibrous tissue is unable ...
Investigation of the therapeutic potential of mesenchymal stem/stromal cells in preclinical models of systemic sepsis
(NUI Galway, 2020-10-29)
Introduction:
Sepsis is a syndrome of life-threatening physiologic, pathologic, and biochemical abnormalities resulting from infection 1. The host immune response, specifically the loss of immune homeostasis induced by ...
Role of gastro-oesophageal reflux in the development and severity of bronchiectasis
(NUI Galway, 2020-07-30)
Background:
Bronchiectasis is a chronic lung disease associated with significant morbidity and mortality, escalating public health costs and profound reductions in health-related quality of life (QoL). Comorbidity is a ...
Environmental and genetic risk factors in Autism Spectrum Disorder: a stereological study
(NUI Galway, 2020-07-15)
Autism spectrum disorders (ASD), include a group of heterogeneous
neurodevelopmental disorders (NDDs) characterized by impaired social interaction,
and communication with restricted patterns of behaviour. The aetiology ...
The role of the liver X receptor in mitotane therapy in adrenocortical carcinoma
(NUI Galway, 2020-08-12)
Adrenocortical carcinoma (ACC) is a rare, aggressive malignancy with limited treatment options. The Liver X Receptor α (LXRα) is highly expressed in the adrenal cortex, and functions to regulate cholesterol and lipid ...
Medical devices for the minimally invasive delivery of therapeutic cargo for the prevention of heart failure
(NUI Galway, 2020-11-10)
Therapeutic advances are increasing the number of patients that survive cardiac disease
such as a myocardial infarction, however, current treatments do not fully stop the
development of heart failure. Advanced therapeutic ...
Exploration of the opioidergic system in the olfactory bulbectomized rat model of depression
(NUI Galway, 2020-02-27)
In recent years, there has been renewed interest in targeting the central opioid system as a novel strategy for the treatment of psychiatric disorders such as depression, due to its involvement in the regulation of mood, ...
The potential of GDF5-functionalised collagen hydrogels to enhance dopaminergic cell replacement therapies for Parkinson's disease
(NUI Galway, 2020-03-05)
Parkinson’s disease is a progressive neurodegenerative disorder associated with the loss of dopaminergic neurons from the substantia nigra and striatum. Over time, the gold standard pharmacotherapy, L-dopa, loses its ...
The role of the endogenous opioid system in hyperalgesia associated with negative affect
(NUI Galway, 2020-02-26)
Pain and negative affect (anxiety and depression) modulate one another reciprocally. However, the neurobiological mechanisms underlying this interaction are unclear. The endogenous opioid system plays a key role in regulating ...
Mitochondrial pathway of apoptosis controls muscle differentiation
(NUI Galway, 2020-09-01)
Caspases are the core compartments of programmed cell death. Caspases also play non apoptotic roles in cell proliferation, migration, differentiation, and immunity. During myoblast differentiation, caspase-2, -9 and -3 are ...