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Now showing items 131-140 of 214
Mechanistic insights into novel cellular therapy strategies for the treatment of corneal allograft rejection
(NUI Galway, 2019-02-14)
It has previously been demonstrated by our lab that tolerogenic dendritic cells (tDCs) prolong corneal allograft survival. This study revealed that tDCs had significantly higher levels of sialic acid on the cell surface ...
In vitro, pre-clinical and commercial evaluation of a novel xeno- and serum-free culture system for production of human bone marrow derived mesenchymal stem cells for bone regeneration
(2016-10-21)
The therapeutic potential of mesenchymal stem cells (MSCs) is recognised in treating a wide range of debilitating diseases. For clinical-scale manufacturing, serum-free and xenogenic-free media formulations have been ...
The role of the liver X receptor in mitotane therapy in adrenocortical carcinoma
(NUI Galway, 2020-08-12)
Adrenocortical carcinoma (ACC) is a rare, aggressive malignancy with limited treatment options. The Liver X Receptor α (LXRα) is highly expressed in the adrenal cortex, and functions to regulate cholesterol and lipid ...
Patient involvement in measuring and monitoring patient safety in general practice
(NUI Galway, 2022-07-01)
Given their unique viewpoint at the epicentre of the care process, patients can make
a unique contribution to improving our understanding of safety in general practice.
Despite this, patients remain an underutilised ...
Human stem cell modeling for amyotrophic lateral sclerosis
(NUI Galway, 2022-09-28)
Amyotrophic lateral sclerosis (ALS) is a fatal and progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons (MNs). Most ALS cases are sporadic, with no family history or known genetic ...
Evaluation of antibiotic resistant enterobacterales in the Irish environment
(NUI Galway, 2022-10-03)
Antibiotic resistance represents a significant public health challenge of global magnitude. In particular, infections caused by extended spectrum beta-lactamase (ESBL) and carbapenemase producing Enterobacterales (CPE) ...
Medical devices for the minimally invasive delivery of therapeutic cargo for the prevention of heart failure
(NUI Galway, 2020-11-10)
Therapeutic advances are increasing the number of patients that survive cardiac disease
such as a myocardial infarction, however, current treatments do not fully stop the
development of heart failure. Advanced therapeutic ...
Exploration of the opioidergic system in the olfactory bulbectomized rat model of depression
(NUI Galway, 2020-02-27)
In recent years, there has been renewed interest in targeting the central opioid system as a novel strategy for the treatment of psychiatric disorders such as depression, due to its involvement in the regulation of mood, ...
Epigenetic regulation of NOD-like receptor activity and expression
(NUI Galway, 2018-11-19)
NOD-like receptors (NLRs) are a family of intracellular pathogen recognition receptors involved in the innate immune response. NOD1 and NOD2 are the best characterised members of this family, and so are the focus of this ...
The potential of GDF5-functionalised collagen hydrogels to enhance dopaminergic cell replacement therapies for Parkinson's disease
(NUI Galway, 2020-03-05)
Parkinson’s disease is a progressive neurodegenerative disorder associated with the loss of dopaminergic neurons from the substantia nigra and striatum. Over time, the gold standard pharmacotherapy, L-dopa, loses its ...