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Metal-based theranostic and therapeutic agents for the targeted treatment and imaging of tumors
(NUI Galway, 2024-01-12)
The present PhD thesis resulted from the undertaking of two separate research projects, both
anyway being strictly related to the rational design of metal complexes with potential
therapeutic and/or diagnostic ...
Synthesis and evaluation of multivalent ligands for macrophage galactose C-type lectin. Development of new chemical tools for immunological research and structural investigation of the lectin with GalNAc and derivatives
(NUI Galway, 2019-09-30)
Synthetic chemistry can provide powerful tools to explore the correlation between an antigen’s
chemical structure and the type of immune response triggered. This thesis work has focused
on the design, synthesis and ...
Small-molecule-based crosslinking and bioconjugation of biomolecules
(NUI Galway, 2020-01-10)
Chapter 1: The chemical modification and bioconjugation of proteins is an expanding yet challenging area of chemical biology. The superior nucleophilicity of cysteine presents it as a uniquely reactive bioconjugation handle. ...
Toward dual-action platinum(IV) complexes with bioactive ligands as potent anticancer agents
(NUI Galway, 2020-02-20)
Platinum agents (cisplatin, carboplatin and oxaliplatin) have a crucial role in the treatment of many cancers for several decades. However, they have severe side effects and a high number of patients have intrinsic or ...