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Advances in ruthenium-based light harvesting materials and photocatalysis: From molecular photosensitizers to photoactive frameworks
(NUI Galway, 2022-04-08)
The presented manuscript deals with the areas of light harvesting and photocatalysis in solar chemistry. The work presented is divided into several sections, beginning with an introductory chapter on the main topics involved ...
Small–molecule reagents and building–blocks for protein materials and bioconjugation
(NUI Galway, 2023-04-18)
The molecular and functional diversification conferred by posttranslational modification
(PTM) of proteins is a common target and source of inspiration for chemical biologists.
For example, the formylglycine-generating ...
Mediated glucose biosensors for application in continuous glucose monitoring
(NUI Galway, 2023-04-19)
Diabetes affects 1 in 11 people globally and requires monitoring of blood glucose
levels as a part of its treatment. Initial blood glucose monitoring devices involved
finger prick testing at regular intervals daily, a ...
Peroxidase-based electrochemical detection using osmium complexes as mediators: application to sensing and immunoassays
(NUI Galway, 2023-05-16)
Horseradish peroxidase (HRP) is an oxidoreductase enzyme that has been used in many bio-electrochemical applications such as biosensors, immunoassays, fuel cells etc. Osmium polypyridyl complexes are advantageous as mediators ...
Metal-based glycoconjugates for the targeted anticancer chemotherapy
(NUI Galway, 2023-08-30)
Rapidly dividing tumor cells require higher amounts of nutrients and energy to sustain their
abnormal proliferation rates, and glucose is no exception. Glucose enters the cell by facilitated
diffusion through the glucose ...
Design and synthesis of biocompatible metal-organic frameworks for anti-cancer, anti-tubercular and MRI application
(NUI Galway, 2023-07-11)
Metal-organic frameworks (MOFs) are relatively new porous materials that have attracted significant
attention in recent decades. Potential applications in gas storage and separation have been at the
forefront of this ...
Part 1: Palladium catalysed deuteration of indoles: Part 2: Development of vovel inhibitors for influenza hemagglutinin
(NUI Galway, 2024-04-10)
For the first two years of my Ph.D programme, I conducted research under the
supervision of Dr. Miriam O’Duill. This research is outlined in Part 1 of this thesis.
Following Dr. O.Duill’s appointment at the University ...
Design, synthesis and evaluation of glycomimetics as galectin inhibitors
(NUI Galway, 2024-03-11)
Chapter-1: This chapter begins with a short review on carbohydrates and their structure and
then summarises some highlights from the last two decades of research on developing
carbohydrate-based drug candidates. Included ...
Design and synthesis of novel constrained glycomimetics as inhibitors of galectins and galactosidases
(NUI Galway, 2023-10-10)
Chapter 1 gives a brief introduction to carbohydrate structure, discussing factors influencing
reactivity and conformation, such as the anomeric and exo-anomeric effect. Chapter 1 mentions
methods of structural analysis ...
Studies of Lewis acid promoted anomerisation reactions
(NUI Galway, 2023-01-23)
The stereoselective synthesis of the glycosidic bond still remains a challenge for the synthetic
carbohydrate chemist. Lewis acid promoted anomerisation offers a useful means of generating
1,2-cis glycosides from their ...