Browsing University of Galway Theses (PhD Theses) by Title
Now showing items 1521-1540 of 2245
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Novel high-resolution imaging modalities for monitoring in vitro models of cartilage degeneration and mesenchymal stem cell therapy in osteoarthritis
(NUI Galway, 2023-06-20)Osteoarthritis (OA) is a chronic disease of synovial joints characterized by progressive degeneration of articular cartilage causing pain and disability in millions of people worldwide. Current imaging systems used for ... -
Novel insights into allele-specific expression and translation in human lymphoblastoid cell lines through integrative analysis of transcriptomic and ribosome profiling data
(NUI Galway, 2018-08-20)The rate of mRNA translation makes an important contribution to determining protein abundance in cells and genetic variants that affect the rate at which a protein is synthesized may give rise to human genetic diseases and ... -
Novel Insights into Chromatin Structure and Gene Regulation through Integrative Analysis of High Throughput Genomics Data
(2014-01-14)Genetics and epigenetics research has evolved dramatically over the last decade, owing to rapid developments in high-throughput genomics techniques. Analysis of the resulting quantities of data requires advanced computational ... -
Novel insights into the molecular roles of UBP5 in controlling chromatin dynamics and plant development
(NUI Galway, 2023-04-03)Polycomb group (PcG) proteins are conserved chromatin regulators essential for controlling key developmental programs in eukaryotes. PcG proteins assemble together to form multi-protein complexes known as Polycomb ... -
Novel mechanisms for neoadjuvant chemotherapeutic response monitoring in breast cancer
(2016-11-25)Breast cancer is the most frequently diagnosed female malignancy worldwide, causing the majority of cancer-related deaths amongst women. While the management of this disease has transformed dramatically in recent years, ... -
Novel mechanobiological modelling of bone metastasis reveals that substrate stiffness, biochemical bone cell signaling and mechanical stimulation alter metastatic activity
(NUI Galway, 2023-03-01)For more than 70% of breast cancer patients, cancer cells spread from their primary site and metastasize to bone. Although much research has been conducted to understand the pathogenesis of the metastatic bone disease, ... -
Novel methods for the planning and design of greenways for cycling
(2016-05-12)There is a crisis in transport internationally as the continuing proliferation of car-use undermines environment, society and economy. Cycling has gained considerable attention in policy and academia in recent years as one ... -
Novel methods of benthic habitat assessment in designated waterbodies around Ireland
(2017-01-06)The European Union has implemented some of the most progressive conservation Directives in the world. These Directives are implemented in different ways, have different reporting cycles and use unique terminologies. The ... -
Novel multiplex isothermal nucleic acid amplification technologies for the detection of bacterial meningitis associated pathogens
(NUI Galway, 2019-02-28)Infectious diseases, caused by pathogenic microorganisms such as bacteria, fungi or viruses, are a leading cause of significant global morbidity and mortality, with over 10 million associated deaths reported each year. ... -
Novel strategies for exploitation of milk glycoproteins for food ingredient applications
(NUI Galway, 2019-08-02)This thesis sets out to explore the potential bioactivities associated with the bovine milk proteome with a view to improving our understanding of the roles bovine milk proteins may play in human health promotion. The ... -
Nuachainteoirí agus Euskaldunberriak: Mudes, idé-eolaíochtaí teanga agus féiniúlachtaí
(NUI Galway, 2020-02-28)Staidéar sochtheangeolaíoch criticiúil atá sa tráchtas seo, ina mbreathnaím ar mudes teangeolaíocha, idé-eolaíochtaí teanga agus féiniúlachtaí nuachainteoirí óga na Gaeilge. Bainim leas as comhthéacs na Bascaise, agus ... -
Nucleolar DNA damage within the female gametophyte perturbs development and genome stability in Arabidopsis thaliana
(NUI Galway, 2021-12-10)The 45S rRNA genes (rDNA) are among the largest repetitive elements in eukaryotic genomes. rDNA consists of tandem arrays of rRNA genes, many of which are transcriptionally silenced. Silent rDNA repeats may act as ‘back-up’ ... -
Nucleolar reorganisation promotes repair of rDNA double strand breaks by homologous recombination throughout the cell cycle.
(2013-12-16)The nucleolus is the largest functional domain within the nucleus and is the site of ribosome biogenesis. It has a distinct structure and houses ribosomal RNA gene (rDNA) transcription, pre-ribosomal RNA (pre-rRNA) processing, ... -
Nucleosome organisation and CENP-C distribution at satellite-free centromeres in Equus asinus
(2017-02-15)Centromeres are distinct epigenetic loci present in single copy per chromosome. Defined by the presence of the histone H3 variant CENP-A, centromeres play a vital role in chromosome segregation via the kinetochore and ... -
Numerical and analytical modelling of friction pile group settlement performance in clay
(2015-01-27)Over the past couple of decades, the focus of foundation design has shifted from ultimate limit state to serviceability limit state, particularly where ground conditions are challenging. Nowadays, the serviceability of a ... -
Numerical Modelling and Measurement of Spatial Coherence in a Lithographic System
(2011-09-30)For the last five decades, optical lithography has been used universally for the manufacture of integrated circuits. The drive towards smaller circuit feature size, and the resulting increase in resolution of lithography ... -
A numerical modelling investigation of jellyfish transport and swimming behavior in Killary Harbour using a coastal hydrodynamic model
(NUI Galway, 2024-01-24)The occurrence of jellyfish in coastal areas, particularly in large numbers or swarms, can pose a significant threat to tourism and aquaculture. They can sting swimmers and bathers, become entangled in fishing nets, ... -
A numerical modelling investigation of the wave resource at Ireland's wave energy test sites
(2017-09)Ocean wave energy harvesting research and development has grown in recent years and wave energy conversion to electricity using wave energy converters (WECs) on a commercial scale is also becoming more realistic. This ... -
Numerical modelling of small groups of stone columns
(2012-09-21)Vibro stone columns, installed using the vibro replacement technique, are a cost effective form of ground improvement for enhancing the bearing capacity and settlement characteristics of various soil types. Large groups ... -
Nurses and midwives in the state sector in Galway
(2014-08-29)Abstract Much has been written about the early years of nursing and the emergence of nursing as a profession. This study continues the story of nursing and midwifery after registration and on into Ireland in the ...