NUI Galway Theses (PhD Theses): Recent submissions
Now showing items 1-20 of 1119
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Marine biodiscovery from Floridian mangrove forests and Irish waters
(2017-08-23)Natural products have been used since ancient times to treat illnesses and terrestrial organisms have been studied extensively from a chemical point of view. Marine organisms, on the other hand are definitely understudied ... -
The need for and effectiveness of an individualised therapeutic programme for people living with prolonged disorders of consciousness in non-specialist care settings in the Republic of Ireland
(2016-11-16)Introduction: Disorders of consciousness are an increasing phenomena and people are living longer with these conditions. The care needs begin with acute medicine and ICU care and frequently end up with life-long nursing ... -
Investigating the epigenetic regulation of toll-like receptor 3
(2017-10-20)Toll-like receptors are a family of pattern recognition receptors (PRRs), which have evolved to recognise structurally conserved components of microorganisms. They form an important part of the innate immune system, yet ... -
Analogous states: John Millington Synge, Zora Neale Hurston, and the performance of ethnography
(2016-12-09)The thesis presents J. M. Synge and Zora Neale Hurston as autoethnographic researcher-practitioners who employed important cultural forms in their theatre, such as the keen and the cakewalk, in order to challenge the ... -
Pure culture, co-culture and whole ecosystem investigations of single anaerobes, partnerships and microbial communities in anaerobic digestion
(2017-10-20)Anaerobic digestion (AD) is a multi-stage process whereby biodegradable material is broken down by complex microbial consortia into renewable CH4 in the absence of oxygen during waste and wastewater treatment. Anaerobic ... -
MicroRNAs as biomarkers and therapeutics in breast cancer
(2017-05-25)Micro(mi)RNAs have potential as both therapeutics and circulating biomarkers of disease. This study investigates potential breast cancer biomarkers miR-138, miR-504 and miR-379. Furthermore, it investigates the impact that ... -
Negotiating the landscape: Prehistoric and early medieval movement in a landscape of esker and bog
(2017-10-20)The aim of this thesis is to understand movement and the evolution of routeways. The role of the individual and their decision-making process is discussed as a fundamental factor in the origins of paths and routeways. This ... -
Predicting the long-term performance of low-cost phosphorus-sorbing materials using small-scale adsorption column experiments
(2017-07-31)Anthropogenic phosphorus (P) and nitrogen (N) inputs to aquatic environments have rapidly increased in magnitude since the middle of the twentieth century, and nutrient pollution has become the primary threat to global ... -
Freedom of expression and the contours of political speech in Ethiopia: Lessons from a comparative study
(2017-08-20)The doctoral thesis studies the scope and application of the right to freedom of expression and the contours of political speech in Ethiopia. In particular, the research focuses on two fundamental areas of speech regulation-the ... -
When paradigms clash: Irish labour market institutions and the unemployment crisis
(2017-10-18)The recent Irish economic and financial crisis had significant impacts on the performance of the labour market and was also associated with major changes to labour market policies and institutions. Drawing on Douglass ... -
Ecosystem services and environmental impacts associated with commercial kelp aquaculture
(2017-07-11)Wild kelp forests represent one of the most productive habitats on Earth, suppling ecosystem services, including, but not limited to, biodiversity, habitat provision, food web subsidy, nutrient cycling, carbon sequestration ... -
Cultural glocalization or resistance? Interrogating the production of YouTube videos at an Irish summer college through practice-based research
(2017-03)This thesis includes the film Dúshlán Lurgan/The Lurgan Challenge and a written exegesis which reflects on the film's 'generative performance'. The film asks if making Irish-language versions of music videos in English at ... -
The dark side of humanity: psychopathy, psychiatry and human nature
(2017-10-11)Psychopathy or antisocial personality disorder is generally conceived as a neurophysiological disorder undermining moral reasoning or sentiment, leading to behaviour which contravenes social and moral norms. This psychiatric ... -
Multiple myeloma: The role of glycosylation in disease development and progression.
(2017-09-09)Multiple myeloma (MM) is a clonal plasma cell disorder that is characterized by skeletal destruction, renal failure, anaemia and hypercalcaemia. MM cells are intimately associated with the bone marrow microenvironment, ... -
Biomaterial scaffolds and genetically modified stem cells - An Investigation of their potential in bone repair
(2017-10-10)The task of repairing large sections of bone tissue lost due to major trauma or pathology poses a significant challenge in orthopedic healthcare. The medical intervention often resorted to consists of a combination of ... -
Quality of life in psychotic illness: baseline and prospective determinants in first episode and chronic psychosis cohorts
(2017-08-01)Abstract The overall aim of this thesis was to longitudinally assess determinants of quality of life in first episode and chronic psychosis patient cohorts. The Galway First Episode Psychosis Cohort Background: In ... -
Energy biographies: Exploring the intersections between lives, practices and contexts
(2017-02)Individual consumption and behaviour change has become a key area of attention in European and Irish sustainable development policy. To date, policy approaches to consumption have been informed by individualised models of ... -
The conservation and sustainable use of biodiversity in areas beyond national jurisdiction of the Costa Rica thermal dome: moving from lex lata to lex ferenda
(2017-09-28)The ocean plays an essential role in environmental, social and economic development worldwide. The aim of the study is to examine the scientific, policy and legal reasons underpinning efforts to ensure the conservation and ... -
Characterisation of the cellular responses to CDC7 inhibition in breast-derived human cells
(2017-10-06)CDC7 plays a role in DNA replication initiation and cell cycle regulation. Inhibition of CDC7 kinase by siRNA triggers a p53-independent apoptotic cell death in cancer cells but not in human fibroblast suggesting this ... -
Endocannabinoid modulation of TLR3-induced neuroinflammation
(2017-10-06)Toll-like receptors (TLRs) play a key role in the recognition and activation of the innate immune system in response to infection. However, aberrant TLR activation has been implicated in predisposing to, and exacerbating, ...