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Smart biomaterials for cell sheet engineering
(2016-03-23)
The aim of this instigation was to develop thermoresponsive polymer films for cell culture use. Conventional cell detachment methods involve the use of proteolytic enzymes, such as trypsin, or mechanical scrapping. These ...
The Reversible Addition-Fragmentation Chain Transfer (RAFT) polymerization of cyanoacrylates
(2018-02-02)
Alkyl 2-cyanoacrylates (CAs) are primarily used as instant adhesives, including those sold under the Loctite brand.
The adhesive action can be inhibited with acid stabilisers allowing radical polymerization to be employed. ...
DNA hybridisation detection on chemically modified electrodes with bioelectrocatalytic amplification of signal
(2011-12-22)
Electrochemical detection of DNA hybridization is a viable alternative to optical and radio-labelled techniques. The benefits of using biosensors based on electrochemical systems are: high sensitivity, possible development ...
The benign synthesis of bioactive heterocycles using photochemistry and hydrogen peroxide with hydrohalic acids
(2016-07-08)
Chapter 1 provides a pertinent review of recent photochemical homolytic aromatic substitution (HAS) literature. Photochemical methods for HAS include UV-light and visible light photoredox catalysis. Recently invented methods ...
The Effects of Electron-Withdrawing Ring Substituents on the Reactivity of Cyclopentadienyl Ruthenium Complexes
(2011-09-09)
This thesis describes the synthesis of ruthenium complexes which contain
cyclopentadienyl ligands with electron-withdrawing ring substituents and the effects of
these substituents on the reactivity of the metal centre. ...
Integrating the old and new: smart thermoresponsive surfaces and 3D fabrication technologies for tissue engineering
(2017-05-08)
One promising direction of regenerative medicine is the development of cell sheet-based tissue-like constructs. The cell sheets preserve ECM and cell−cell junctions. This may greatly support cell adherence to damaged organ ...
Protein-carbohydrate interactions and structural characterization of Ralstonia solanacearum lectin
(2017-03-20)
Ralstonia solanacearum is a bacterium which causes fatal damage to hundreds of agricultural plants such as potato or tobacco. It produces two lectins that are involved in attachment of the bacterium to the host. One of ...
Protein interactions in physiological environments
(2016-06-03)
The interactions of three proteins (ΔTat-GB1, cytochrome c and flavodoxin) were explored in Escherichia coli cells and extracts. The results indicate features of the physicochemical basis for protein assembly in the complex ...
Marine biodiscovery from Floridian mangrove forests and Irish waters
(2017-08-23)
Natural products have been used since ancient times to treat illnesses and terrestrial organisms have been studied extensively from a chemical point of view. Marine organisms, on the other hand are definitely understudied ...
Exploring a novel class of fluorophores: the 2,5-dihydro-1,2,3-triazines
(2016-09-27)
The 1,2,3-triazines, also known as the v-triazines, are the least studied of the three classes of triazine. This is due to the ring’s lower stability and more limited synthetic routes. A new class of fluorophores, based ...