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Now showing items 1711-1720 of 1724
Synthesis and evaluation of multivalent ligands for macrophage galactose C-type lectin. Development of new chemical tools for immunological research and structural investigation of the lectin with GalNAc and derivatives
(NUI Galway, 2019-09-30)
Synthetic chemistry can provide powerful tools to explore the correlation between an antigen’s
chemical structure and the type of immune response triggered. This thesis work has focused
on the design, synthesis and ...
Small-molecule-based crosslinking and bioconjugation of biomolecules
(NUI Galway, 2020-01-10)
Chapter 1: The chemical modification and bioconjugation of proteins is an expanding yet challenging area of chemical biology. The superior nucleophilicity of cysteine presents it as a uniquely reactive bioconjugation handle. ...
The neural network basis of cognitive impairment in bipolar disorder
(NUI Galway, 2020-01-22)
Background: Despite well-documented cognitive deficits that contribute to poorer quality of life in bipolar disorder (BD) and evidence of altered topology and connectivity within neural networks, little work has been done ...
Nuachainteoirí agus Euskaldunberriak: Mudes, idé-eolaíochtaí teanga agus féiniúlachtaí
(NUI Galway, 2020-02-28)
Staidéar sochtheangeolaíoch criticiúil atá sa tráchtas seo, ina mbreathnaím ar mudes teangeolaíocha, idé-eolaíochtaí teanga agus féiniúlachtaí nuachainteoirí óga na Gaeilge. Bainim leas as comhthéacs na Bascaise, agus ...
Sheltered work and intellectual disability equality: Can the UN Convention on the Rights of Persons with Disabilities tackle this form of segregation?
(NUI Galway, 2020-02-13)
This thesis is a theoretical study that addresses the enduring segregation of people with intellectual disabilities in sheltered work environments. Having identified that many people with intellectual disabilities remain ...
A kind of mime: Cultural politics and narrative experiment in the works of Samuel Beckett, Máirtín Ó Cadhain, and Brian Ó Nualláin
(NUI Galway, 2019-09-27)
This thesis is a trilingual comparative literary study, analysing the works of Samuel Beckett (1906-1989), Máirtín Ó Cadhain (1906-1970), and Brian Ó Nualláin (1911-1966). This study will argue that the very particular ...
Sustainable treatment technologies using mixed waste media to mitigate agricultural contaminants in land drainage
(NUI Galway, 2020-01-30)
Intensification of agriculture in the European Union has resulted in nutrient losses from farms, which have contributed to a deterioration in water quality. As soil in drainage water ditch networks has limited capacity to ...
Developing the evidence base for preschool social circles: An intervention to support social inclusion for children with autism spectrum disorder
(NUI Galway, 2020-03-02)
Background
Successful social inclusion in early childhood education is associated with positive
outcomes for all children in later life, irrespective of disabilities or complexity of needs.
Many children with additional ...
Glycosylation in the injured and regenerating spinal cord, and the influence of biomaterial treatment
(NUI Galway, 2020-02-04)
Traumatic spinal cord injury (SCI) results in disruption of tissue integrity leading to a loss of function. There has been minimal success in treating these injuries clinically, due to the inhibitory environment which ...
Identification of plant-specific components of the Polycomb Group pathway and their roles in the regulation of Arabidopsis thaliana development
(NUI Galway, 2019-09-30)
The knowledge about Arabidopsis thaliana developmental life cycle is deep in broad strokes. Nevertheless, the mechanisms that fine tune these phase transitions are still poorly described. One of these mechanisms is the ...