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Now showing items 581-590 of 875
Game-based learning to engage students with physics and astronomy using a board game
(IGI Global, 2019)
In this research article, the authors developed a novel astronomy board game and examined how this
approach could facilitate the learning and teaching of astronomy topics covered in the new Irish Science
Syllabus. A total ...
Revealing biomedically relevant cell and lectin type-dependent structure–activity profiles for glycoclusters by using tissue sections as an assay platform
(Royal Society of Chemistry, 2018-08-14)
The increasing realization of the involvement of lectin-glycan recognition in (patho)physiological processes inspires envisioning therapeutic intervention by high-avidity/specificity blocking reagents. Synthetic glycoclusters ...
Merging carbohydrate chemistry with lectin histochemistry to study inhibition of lectin binding by glycoclusters in the natural tissue context
(Springer, 2015-11-09)
Recognition of glycans by lectins leads to cell adhesion and growth regulation. The specificity and selectivity of this process are determined by carbohydrate structure (sequence and shape) and topology of its presentation. ...
A kinetic modelling study of alcohols operating regimes in a HCCI engine
(SAE International, 2017-09-04)
Pursuing a sustainable energy scenario for transportation requires the blending of renewable oxygenated fuels such as alcohols into commercial hydrocarbon fuels. From a chemical kinetic perspective, this requires the ...
Cost-effective wireless microcontroller for internet connectivity of open-source chemical devices
(American Chemical Society, 2018-06-04)
This paper presents a system for remote monitoring of turbidity data that can detect light intensity and temperature using a microcontroller and the Internet of Things. The system comprises a light dependent resistor and ...
A phosphate-targeted dinuclear Cu(II) complex combining major groove binding and oxidative DNA cleavage
(Oxford University Press, 2018-09-17)
Free radical generation is an inevitable consequence of aerobic existence and is implicated in a wide variety of pathological conditions including cancer, cardiovascular disease, ageing and neurodegenerative disorder. Free ...
Cocrystal forms of the BCS class IV drug sulfamethoxazole
(American Chemical Society, 2018-05-23)
Sulfamethoxazole, smz, is an antibiotic that is classified as a Biopharmaceutics Classification System (BCS) class IV, low solubility and low permeability drug. Cocrystal formation has been examined in an attempt to improve ...
Teaming up synthetic chemistry and histochemistry for activity screening in galectin-directed inhibitor design
(Springer, 2016-06-24)
A hallmark of endogenous lectins is their ability to select a few distinct glycoconjugates as counterreceptors for functional pairing from the natural abundance of cellular glycoproteins and glycolipids. As a consequence, ...
Ligand design for somatostatin receptor isoforms 4 and 5
(Elsevier, 2018-11-17)
The somatostatin receptor (SSTR) isoforms, SSTR-4 and SSTR-5 are targets in numerous disorders and diseases. Although there has been some success in achieving selective isoform inhibition, structure-based drug design and ...
Influence of initial residual stress on growth and pattern creation for a layered aorta
(Nature Research, 2019-06-03)
Residual stress is ubiquitous and indispensable in most biological and artificial materials, where it sustains and optimizes many biological and functional mechanisms. The theory of volume growth, starting from a stress-free ...