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Dual-drug amorphous formulation of gliclazide
(Taylor and Francis, 2021-02-01)
Amorphization is a well-established strategy to enhance the dissolution properties of poorly water-soluble drugs. However, the amorphous state is inherently unstable toward recrystallization. Coamorphous systems of a drug ...
Electro-mechanically guided growth and patterns
(Elsevier, 2020-07-01)
Several experiments have demonstrated the existence of an electro-mechanical effect in many biological tissues and hydrogels, and its actual influence on growth, migration, and pattern formation. Here, to model these ...
Comprehensive experimental and simulation study of the ignition delay time characteristics of binary blended methane, ethane, and ethylene over a wide range of temperature, pressure, equivalence ratio, and dilution
(American Chemical Society, 2020-06-03)
A comprehensive experimental and kinetic modeling study of the ignition delay time (IDT) characteristics of some binary blends of C1–C2 gaseous hydrocarbons such as methane/ethylene, methane/ethane, and ethane/ethylene was ...
A comprehensive experimental and simulation study of ignition delay time characteristics of single fuel C1–C2 hydrocarbons over a wide range of temperatures, pressures, equivalence ratios, and dilutions
(American Chemical Society, 2020-02-03)
A comprehensive experimental and modeling study of the ignition delay time (IDT) characteristics of some single prominent C1–C2 hydrocarbons including methane, ethane, and ethylene has been performed over a wide range of ...
Genes regulated by BCL11B during T‐cell development are enriched for de novo mutations found in schizophrenia patients
(Wiley, 2020-07-29)
While abnormal neurodevelopment contributes to schizophrenia (SCZ) risk, there is also evidence to support a role for immune dysfunction in SCZ.BCL11B, associated with SCZ in genome-wide association study (GWAS), is a ...
Development of Mcl-1 inhibitors for cancer therapy
(Elsevier, 2020-11-24)
The myeloid leukemia cell differentiation protein (Mcl-1) is an anti-apoptotic protein of the B-cell lymphoma 2 (Bcl-2) family, which regulates cellular apoptosis. Mcl-1 expression plays a key role in survival of cancer ...
Electrochemical glucose biosensor based on an osmium redox polymer and glucose oxidase grafted to carbon nanotubes: A design-of-experiments optimisation of current density and stability
(Elsevier, 2021-01-25)
Enzymatic glucose electrodes based on mediated electron transfer have potential for application as semi-implantable or implantable sensors. Enzyme electrodes consisting of adsorbed osmium-based redox polymer crosslinked ...
Propionate production by bioelectrochemically-assisted lactate fermentation and simultaneous CO2 recycling
(Frontiers Media, 2020-12-15)
Production of volatile fatty acids (VFAs), fundamental building blocks for the chemical industry, depends on fossil fuels but organic waste is an emerging alternative substrate. Lactate produced from sugar-containing waste ...
An experimental and kinetic modeling study of cyclopentane and dimethyl ether blends
(Elsevier, 2020-11-13)
Cyclopentane is a suitable naphthene, or cycloalkane, in a palette for multi-component gasoline surro- gate fuels due to its presence in market fuels and its relevance to alkyl substituted cyclopentanes also present. ...
The influence of iso-butene kinetics on the reactivity of di-isobutylene and iso-octane
(Elsevier, 2020-09-06)
The continuous development of a core C-0 - C-4 kinetic mechanism generally involves updating it using reliable kinetics and thermodynamics and may also involve the inclusion of missing reaction pathways to improve the ...