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The very different effect of water on nucleation, crystallization, and hydrate stability of zingerone and vanillate esters
(American Chemical Society, 2020-01-09)
Vanillin and vanillate esters are widely used as flavorings in the food industry, and the vanillin derivative zingerone is one of the compounds found in the spice ginger. Neither the growth of single crystals of zingerone ...
Unprecedented morphology control of gas phase cocrystal growth using multi zone heating and tailor made additives
(Royal Society of Chemistry, 2020-04-15)
Herein, it is shown for the first time that cocrystals can be grown by cosublimation with unprecedented morphology control using tailor made additives. Multicrystalline sea-urchin motifs and solids that look like candy-floss ...
Crystallization of organic salts from the gas phase: When does proton transfer take place?
(American Chemical Society, 2020-12-13)
Salt formation with proton transfer is observed in crystals grown by cosublimation of the salt coformers. Diflunisal salts were obtained with 4-[3-(pyridin-4-yl)propyl]pyridine, piperazine, and 4-dimethylaminopyridine. ...
Salts, binary and ternary cocrystals of pyrimethamine: mechanosynthesis, solution crystallization and crystallization from the gas phase
(American Chemical Society, 2020-11-24)
A series of salts and binary and ternary cocrystals of the antimalaria drug pyrimethamine (PYR) are reported. PYR has a donor–acceptor–donor (DAD) and a donor–acceptor (DA) binding site, and cocrystallization experiments ...
Manipulating cocrystal size and morphology using a combination of temperature cycling and additives
(American Chemical Society, 2020-11-20)
A cooling crystallization of benzoic acid and isonicotinamide in ethanol yields the 1:1 cocrystal with an extreme needle-like morphology with an initial mean aspect ratio of ∼10 and a size of ∼64 μm. We demonstrate that ...
Influence of excipients on cocrystal stability and formation
(American Chemical Society, 2020-05-26)
Cocrystal formation is widely used to modify and optimize the physicochemical properties of an active pharmaceutical ingredient (API). However, the stability of cocrystals toward formulation with excipients is little ...
Spontaneous solid-state cocrystallization of caffeine and urea
(American Chemical Society, 2020-01-09)
The cocrystallization of caffeine and urea was monitored and analyzed using infrared spectroscopy, Raman microscopy, scanning electron microscopy, differential scanning calorimetry, and X-ray diffraction. The caffeine-urea ...
Dual-drug amorphous formulation of gliclazide
(Taylor and Francis, 2021-02-01)
Amorphization is a well-established strategy to enhance the dissolution properties of poorly water-soluble drugs. However, the amorphous state is inherently unstable toward recrystallization. Coamorphous systems of a drug ...