Spontaneous solid-state cocrystallization of caffeine and urea
Crowley, Clare M.
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MacFhionnghaile, Pól, Crowley, Clare M., McArdle, Patrick, & Erxleben, Andrea. (2020). Spontaneous Solid-State Cocrystallization of Caffeine and Urea. Crystal Growth & Design, 20(2), 736-745. doi:10.1021/acs.cgd.9b01152
The cocrystallization of caffeine and urea was monitored and analyzed using infrared spectroscopy, Raman microscopy, scanning electron microscopy, differential scanning calorimetry, and X-ray diffraction. The caffeine-urea cocrystal was shown to form spontaneously over several weeks under low energy mixing of the solids at room temperature and low relative humidity (