Browsing School of Chemistry by Author "Aldabbagh, Fawaz"
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Chain transfer to solvent in the radical polymerization of structurally diverse acrylamide monomers using straight-chain and branched alcohols as solvents
Magee, Christopher; Sugihara, Yusuke; Zetterlund, Per B.; Aldabbagh, Fawaz (Royal Society of Chemistry, 2014-01-02)Chain transfer to solvent in conventional radical polymerizations of N-tert-butylacrylamide (TBAM) and N-(2-morpholin-4-ylethyl) acrylamide (MEA) in a range of alcohol solvents is investigated. Mayo analysis of polymerization ... -
CO2-responsive polyacrylamide copolymer vesicles with acid-sensitive morpholine moieties and large hydrophobic RAFT end-group
Chalmers, Benjamin A.; Magee, Christopher; Cheung, David L.; Zetterlund, Per B.; Aldabbagh, Fawaz (Elsevier, 2017-10-07)Sequential Reversible Addition Fragmentation Chain Transfer (RAFT) polymerizations using 2,2′-azobis[2-(2-imidazolin-2-yl)propane]dihydrochloride (VA-044) and 2-(dodecylthiocarbonothioylthio)-2-methylpropionic acid ... -
Discovery of anti-cancer activity for benzo[1,2,4]triazin-7-ones: Very strong correlation to pleurotin and thioredoxin reductase inhibition
Sweeney, Martin; Coyle, Robert; Kavanagh, Paul; Berezin, Andrey A.; Lo Re, Daniele; Zissimou, Georgia A.; Koutentis, Panayiotis A.; Carty, Michael P.; Aldabbagh, Fawaz (Elsevier, 2016-05-30)The thioredoxin (Trx)-thioredoxin reductase (TrxR) system plays a key role in maintaining the cellular redox balance with Trx being over-expressed in a number of cancers. Inhibition of TrxR is an important strategy for ... -
A new era for homolytic aromatic substitution: replacing Bu3SnH with efficient light-induced chain reactions
Gurry, Michael; Aldabbagh, Fawaz (Royal Society of Chemistry, 2016-04-01)Herein is a pertinent review of recent photochemical homolytic aromatic substitution (HAS) literature. Issues with using the reductant Bu3SnH in an oxidative process where the net loss of a hydrogen atom occurs is discussed. ... -
One-pot hydrogen peroxide and hydrohalic acid induced ring closure and selective aromatic halogenation to give new ring-fused benzimidazoles
Gurry, Michael; Sweeney, Martin; McArdle, Patrick; Aldabbagh, Fawaz (American Chemical Society, 2015-05-19)A new series of selectively dichlorinated and dibrominated five- to eight-membered-ring [1,2-a]-fused benzimidazoles and [1,4]oxazino[4,3-a]benzimidazoles are synthesized in mostly high yields of >80% using the reaction ... -
RAFT polymerization in supercritical carbon dioxide based on an induced precipitation approach: synthesis of 2-ethoxyethyl methacrylate/acrylamide block copolymers
Hawkins, Gerard; Zetterlund, Per B.; Aldabbagh, Fawaz (Wiley, 2015-05-13)A new controlled/living heterogeneous polymerization technique using RAFT in benign supercritical CO2 is described involving the formation of monomer-swollen seed particles by precipitation of macroRAFT agent prior to ... -
Synthesis of fluorinated alkoxyamines and alkoxyamine-initiated nitroxide-mediated precipitation polymerizations of styrene in supercritical carbon dioxide
Magee, Christopher; Earla, Aruna; Petraitis, Jennifer; Higa, Chad; Braslau, Rebecca; Zetterlund, Per B.; Aldabbagh, Fawaz (Royal Society of Chemistry, 2014-06-20)TIPNO (2,2,5-trimethyl-4-phenyl-3-azahexane-3-nitroxide)-alkoxyamine was found to give reasonably controlled/living nitroxide-mediated (NMP) precipitation polymerizations of styrene in supercritical carbon dioxide (scCO(2)). ... -
Tandem reactions via Barton Esters with intermolecular addition and vinyl radical substitution onto indole
Coyle, Robert; McArdle, Patrick; Aldabbagh, Fawaz (American Chemical Society, 2014-05-16)A one-pot initiator-free Barton ester decomposition with tandem radical addition onto alkyl propiolates or phenylacetylene with aromatic substitution of the resultant vinyl radical allows convenient access to new 9-substituted ...