Browsing University of Galway Theses (PhD Theses) by Subject "Department of Chemistry"
Now showing items 1-10 of 10
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The anomerisation of glycosidic linkages
(2014-04-07)This thesis deals with the anomerisation of glycosidic linkages using TiCl4 and SnCl4. Methods involving the Lewis acid induced anomerisations of glycosides have been published over the past decade, however this methodology ... -
Barton esters for initiator-free radical cyclisation with heteroaromatic substitution and anti-cancer evaluation of benzo[e][1,2,4]triazin-7-ones
(2014-07-03)Chapter 1 provides a general introduction to Chapters 2-5. Homolytic aromatic substitution routes to alicyclic ring-fused azoles and diazoles is reviewed. A review of recent literature using the COMPARE program of the ... -
Computational design of glycomimetic inhibitors of Influenza A Adhesion
(2015-02-16)Many pathogens, such as avian influenza, Helicobacter pylori and Streptococcus pneumoniae, employ cell-surface glycans which terminate in Neu5AcAlpha(2-3)Gal as their adhesion partner.[1] As a result, a glycomimetic ... -
Computationally Guided Directed Evolution of O-GlcNAcase into a Reagent Specific for [beta]-O-GlcNAc
(2013-12-13)Protein glycosylation with O-linked N-Acetylglucosamine (O-GlcNAc) is a post-translational modification of serine and threonine residues in nucleocytoplasmic proteins. Alterations in the glycosylation pattern of O-GlcNAc ... -
Development of Mediated Enzymatic Fuel Cells for Operation in Blood
(2013-07)The process of enzymatic catalysis of glucose oxidation releases electrons which, when harnessed to flow through a circuit, may be utilised to power devices. This principle has driven research towards the goal of providing ... -
Exploring synthetic strategies towards novel magnetic materials - a structural, magnetic and spectroscopic study
(2015-09-03)This thesis reports the exploration of various synthetic strategies towards the synthesis of novel magnetic materials, which were studied both structurally and spectroscopically. An outline of results chapters is given ... -
Expression, purification and characterization of carbohydrate-binding proteins
(2014-05-29)Glycans play important roles in many biological interactions. They are involved in cell-cell interactions, function as a point of entry for viral infections and facilitate the adhesion of microbes in the body. Glycans of ... -
Nitroxide Mediated Radical Heterogeneous Polymerizations in Supercritical Carbon Dioxide
(2012-03-05)Chapter 1 provides a general introduction to addition radical polymerizations and controlled/living radical polymerizations with an emphasis on nitroxide-mediated polymerization (NMP). The merits of supercritical carbon ... -
Ouantitative, Non-Contact Measurements of the Physicochemical Properties of Thermoresponsive Polymers using Fluorescence Methods.
(2011-09-30)In biomedical science and engineering the use of microscale thin polymer films is widespread. These polymer films are often formed on complex geometries which can provide problems for in-situ analysis and the accurate ... -
Synthesis and Application of Chiral AraBOX ligands for Asymmetric Catalysis
(2012-11-28)This thesis deals with the design, synthesis and reactivity of novel 4,4'-bisoxazoline ligands and their metal complexes; (S,S)-MePrAraBOX, (S,S)-PhPrAraBOX, (S,R)-MePrAraBOX, (S,R)-PhPrAraBOX, (S,R)-BnOAcAraBOX and ...