Browsing University of Galway Theses (PhD Theses) by Subject "Anatomy"
Now showing items 1-20 of 20
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Advanced therapies in pancreatic islet transplantation for type 1 diabetes mellitus
(NUI Galway, 2023-03-14)Type 1 diabetes mellitus is an autoimmune condition whereby β-cells are destroyed by the immune system causing the lack/absence of insulin production and resultant hyperglycaemia. Pancreatic islet transplantation is ... -
Analysis of the role of Rho GTPases in epithelial cells
(2014-11-19)Rho GTPases are a family of small GTP binding proteins that function as molecular switches for the control of a variety of fundamental cellular processes, and therefore represent potentially vital proteins for skin ... -
Development of novel biomaterials and medical devices to improve diabetes treatment and ambient cell transportation
(NUI Galway, 2023-02-08)Diabetes mellitus is a global pandemic affecting to more than 500 million people worldwide, with Type 1 diabetics being the most at risk due to life-threatening hyper and hypoglycaemic complications. Islet transplantation ... -
Dissecting the monster: mapping discourses of medicine, ethics, and monstrosity in the Victorian Penny Blood
(2017-02-02)This research analyses a set of specimens of penny blood literature from the point of view of medical history, with the goal of providing an examination of the genre in relation to its historical context. In so doing, it ... -
Dynamics of GFP tagged chromatin factors RSF1, CENPS and CENPX at microirradiation induced DNA damage sites
(NUI Galway, 2022-02-22)Chromatin has a major influence on the DNA damage response (DDR). Several chromatin-related factors contribute to the DDR including the CENPS and CENPX histone fold proteins, also known as MHF1 and MHF2, and the chromatin ... -
Environmental and genetic risk factors in Autism Spectrum Disorder: a stereological study
(NUI Galway, 2020-07-15)Autism spectrum disorders (ASD), include a group of heterogeneous neurodevelopmental disorders (NDDs) characterized by impaired social interaction, and communication with restricted patterns of behaviour. The aetiology ... -
Ex Vivo slice culture model of rat spinal cord injury as a platform for testing proposed treatment strategies
(NUI Galway, 2018-04-13)There are several detrimental events that occur in the aftermath of a spinal cord injury (SCI); these include glial scar formation, accumulation of axon growth inhibitors and immune mediators. These events present challenges ... -
FibroSensing Dynamic Soft Reservoir (FSDSR): A bio-sensing drug delivery device for monitoring the foreign body response in real time
(NUI Galway, 2022-12-19)Despite significant advancements in Type 1 diabetes mellitus (Type 1 DM) treatments, the foreign body response continues to prevent the longevity of implantable medical devices that treat the condition. The development ... -
Glycosylation in the injured and regenerating spinal cord, and the influence of biomaterial treatment
(NUI Galway, 2020-02-04)Traumatic spinal cord injury (SCI) results in disruption of tissue integrity leading to a loss of function. There has been minimal success in treating these injuries clinically, due to the inhibitory environment which ... -
The impact of alcohol consumption on brain networks: Investigating differential effects in bipolar disorder
(NUI Galway, 2022-03-30)Background: Widespread alterations to cortical regions particularly in areas related to reward processes have been described following non-dependent alcohol use and independently in bipolar disorder (BD). Additionally, ... -
The impact of childhood trauma on structural brain connectivity in schizophrenia: A diffusion MRI and network based study
(NUI Galway, 2021-12-29)Schizophrenia is a severe and heterogeneous neuropsychiatric disorder affecting approximately 1% of the world’s population. In recent years, exposure to childhood trauma has been established as a prominent environmental ... -
Implications of histone H2AX abundance in breast cancer
(NUI Galway, 2019-12-09)Histones are responsible for the packaging of DNA into a eukaryotic cell nucleus, and the H2A variant H2AX plays an important role in the DNA damage response (DDR). The phosphorylated form of H2AX, known as γH2AX, has been ... -
Improving the function and longevity of implantable drug and cell delivery devices by overcoming the foreign body response
(NUI Galway, 2023-02-23)The success of implantable medical devices is hindered by an inevitable inflammatory response called the Foreign Body Response. The human body recognises any implanted biomaterial as a foreign object, and isolates it ... -
An investigation of neuroanatomical contributions to cognitive deficits associated with psychotic illness: A 4 year longitudinal follow-up study
(2017-02-20)Introduction: In general, individuals who experience a first-episode of psychosis (FEP) display deficits on a wide range of neuropsychological tasks compared to psychiatrically healthy individuals (Bora et al., 2014). ... -
Medical devices for the minimally invasive delivery of therapeutic cargo for the prevention of heart failure
(NUI Galway, 2020-11-10)Therapeutic advances are increasing the number of patients that survive cardiac disease such as a myocardial infarction, however, current treatments do not fully stop the development of heart failure. Advanced therapeutic ... -
Modulation of inflammatory pain in intervertebral disc degeneration: A therapeutic biomaterials approach
(2017-10-05)Discogenic low back pain (LBP) is a very common health problem that imposes a socio-economic burden on society. Primarily, intervertebral disc degeneration is one of the causative factors of LBP. It is mediated by an ... -
The neural network basis of cognitive impairment in bipolar disorder
(NUI Galway, 2020-01-22)Background: Despite well-documented cognitive deficits that contribute to poorer quality of life in bipolar disorder (BD) and evidence of altered topology and connectivity within neural networks, little work has been done ... -
Regulation of emotion and cholinergic system connectivity in bipolar disorder
(NUI Galway, 2019-10-04)Background: The human brain comprises distributed cortico-subcortical regions that are structurally and functionally connected into a network that is known as the human connectome. Understanding how connections between ... -
A structural and functional characterisation of human term myometrium
(2015-04-27)This thesis encompasses two aims, firstly, to describe the normal anatomy of human term myometrium, as this is not fully characterised in the literature, and secondly, to assess whether this morphology is altered with ... -
Towards an additive manufactured macroencapsulation device for islet cell replacement therapy
(NUI Galway, 2020-07-28)Islet encapsulation devices can induce a Foreign Body Response (FBR) and the formation of a hardened avascular fibrotic capsule. This FBR is heightened when the device features a smooth surface as fibrous tissue is unable ...