Browsing University of Galway Theses (PhD Theses) by Subject "UPR"
Now showing items 1-2 of 2
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The prognostic and therapeutic value of XBP1 signalling in ER-positive breast cancer
(NUI Galway, 2021-04-02)Breast cancer is a heterogeneous disease with distinct subtypes having specific molecular features. Approximately, 75% of breast cancers are estrogen receptor α (ER)-positive. Endocrine therapies have been used as a standard ... -
Role of MicroRNAs and unfolded protein response in breast cancer
(2017-11-24)Stressful conditions of the tumour microenvironment which overwhelm the folding capacity of the endoplasmic reticulum (EnR) activate an evolutionary conserved signalling pathway known as the unfolded protein response (UPR). ...