Browsing University of Galway Theses (PhD Theses) by Subject "Escherichia coli"
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The expression of recombinant proteins with biomedical importance in Escherichia coli
(NUI Galway, 2020-01-30)Naturally-occurring peptides and proteins with diverse biological roles have enormous potential for use as therapeutics and biomaterials. While proteins of biomedical interest were traditionally isolated from their native ... -
Glycosylation and glycoengineering of recombinant antibody fragments in Escherichia coli
(2016-11-14)Recombinant protein production (RPP) in Escherichia coli benefits from a long history of research which has facilitated the development of a plethora of strains and vectors suited to RPP applications. The identification ... -
Investigation of the structure and function of the metal transporter CzrB from Thermus thermophilus and the molecular chaperone trigger factor from Psychrobacter frigidicola by X-ray crystallography
(2014-09-26)A crystallographic approach was taken to investigate the structure and function of two proteins of interest previously isolated in our research group and identified as having potential application in improving the production ... -
Understanding the role of the general stress response regulator, RpoS, in the environmental persistence of Escherichia coli
(2017-04-03)The use of E. coli as an indicator organism for faecal contamination in the environment, particularly in water sources, is based partly on the assumption that E. coli survives transiently outside of the mammalian ...