Browsing University of Galway Theses (PhD Theses) by Subject "Apoptosis"
Now showing items 1-16 of 16
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A cell-based study exploring novel therapeutic approaches to target cell stress and cell death pathways in paediatric cancers
(NUI Galway, 2020-08-17)Paediatric cancer is the leading cause of death by disease in children. High mortality rates and long-term effects of conventional treatments suggest an urgent need for basic and translational research to allow treatment ... -
Cellular response to stress: role of autophagy and cell death in caspase-9 deficient cells
(2017-10-31)Chronic or unresolved stress can lead to cell death, and induction of apoptosis is crucial when the cellular adaptive mechanisms are not able to resolve persistent stress. Malfunction of the apoptotic process caused by ... -
Cellular responses to endoplasmic reticulum stress: Role of autophagy and cell death
(2014-12-03)This PhD thesis describes cellular responses to the induction of endoplasmic reticulum (ER) stress, focusing on the role of autophagy and cell death. Pro-survival role of unfolded protein response (UPR) is analysed by ... -
Characterization of a novel cell death-inducing protein complex assembled in response to stress
(NUI Galway, 2021-01-26)Pro-caspase-8 is the apical caspase in the extrinsic apoptosis which is initiated by the external stimulation of certain death receptors. Pro-caspase-8 is synthesised as an inactive zymogen, which must be cleaved to reach ... -
Cytotoxic drug induced JNK activation is DR5-dependent and vital for apoptosis and provides a new target for MSC-mediated delivery of DR5-specific sTRAIL variants
(2013-03-20)Over the past two decades, cancer research has produced tremendous advances in our understanding of the pathogenesis of cancer. Among the most important of these advances is the realization that apoptosis and the proteins ... -
Decoy Receptors block tumour cell eradication by TRAIL - Molecular engineering of TRAIL to evade decoy receptors
(2012-06-29)Tumour necrosis factor-related apoptosis inducing ligand (TRAIL) is a cytokine expressed by immune cells which selectively eradicates a wide range of cancer cells while leaving normal healthy cells unharmed. TRAIL binds ... -
Exploring the potential of glycogen synthase kinase-3 (GSK3) mediated therapy in castrate-resistant prostate cancer
(2016-11-30)Glycogen Synthase Kinase 3 (GSK3) is involved in a myriad of signalling pathways and has recently received considerable interest due to its conflicting roles tumourigenesis. Though it has classically been regarded as a ... -
Identification of decisive molecular interactions regulating resistance to apoptosis in tumour cells
(14-07-04)TRAIL is a member of the TNF family of cytokines which can selectively induce apoptosis in cancerous cells. For this reason recombinant TRAIL is being considered for the treatment of cancer. During their development cancer ... -
Investigation of various ligand design approaches and synthesis of diverse heterocyclic bioactive compounds
(NUI Galway, 2019-09-27)Structure-based design and ligand-based design are one of the most common approaches used to develop new inhibitors against druggable protein targets in various human disorders. Mcl-1 is a protein belongs to Bcl-2 family ... -
Iodine in Seaweeds - Physiological Significance and Implications for Climate and Health
(2013-01-18)Iodine-rich macroalgae inhabit the subtidal on coasts in temperate regions. The algae-driven release of iodine into the environment has major implications for the biogeochemical iodine cycle a ffecting atmospheric chemistry ... -
Life with crippled microtubules: How yeast and human cells deal with forced microtubule depolymerization
(NUI Galway, 2023-01-25)Microtubule poisons are microtubule targeting agents widely used in cancer treatment. These drugs are given to cancer patients in cycles, and resistant cells can emerge both after the first or the following rounds of ... -
The molecular characterization of ER stress-induced autophagy and cell death
(2012-12-21)Autophagy is tightly regulated by the unfolded protein response (UPR). It plays an important role in the removal of unfolded proteins, damaged mitochondria and expanded endoplasmic reticulum (ER), to help relieve ER stress ... -
NGF-induced pro-survivla signalling: Molecular engineering of NGFto enhance pro-survival signalling
(2014-01-27)Nerve growth factor (NGF) is a potent pro-survival growth factor that has diverse roles in development and in the adult nervous system. It has two cognate receptors that stimulate distinct signalling pathways, tropomyosin-related ... -
Regulators of TRAIL resistance in normal and transformed cells
(2015-05-26)TRAIL is a member of the Tumor Necrosis Factor superfamily which was shown to be able to induce apoptotic cell death in a wide variety of transformed cells, leaving normal, healthy cells unharmed. However, approximately ... -
The role of microRNAs during endoplasmic reticulum stress induced cell death
(2012-04-25)Endoplasmic Reticulum (ER) stress occurs in response to negative insult or stimuli to the cell. It induces a pathway called the unfolded protein response (UPR) which can alleviate stress and restore the cell to its ¿healthy ... -
Thermal elevations of orthopaedic procedures: A bone cell perspective
(2014-05-27)Thermal elevations experienced by bone during orthopaedic procedures, such as cutting and drilling, exothermal reactions from bone cement, and thermal therapies such as tumour ablation, can result in thermal damage leading ...