Browsing University of Galway Theses (PhD Theses) by Author "Seoighe, Cathal"
Now showing items 1-15 of 15
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Analysis and interpretation of epigenomic patterns in colonic epithelia
Barnicle, Alan (2015-12-18)The methylation of cytosine nucleotides at the 5' position of DNA is a crucial epigenetic mechanism for the control of gene expression. Epigenome-wide associated studies have demonstrated that specific methylome patterns ... -
Analysis of clonal mutations in cancer as a means of studying variation in somatic mutation processes
Cleary, Siobhán (NUI Galway, 2023-09-13)Somatic mutations are mutations that arise throughout a person’s lifetime. They contribute to ageing, cancer and other age-related disorders. Recent technological advances led to many studies investigating somatic ... -
Analysis of hepatic microRNA expression in postpartum dairy cows in negative energy balance
Fatima, Attia (2014-05-27)This thesis sets about to answer three research questions grounded in transcriptional regulation of hepatic genes in the high yielding postpartum dairy cow under negative energy balance (NEB). For this purpose we used ... -
Analysis of hepatic microRNA expression in postpartum dairy cows in negative energy balance
Fatima, Attia (2014-05-27)This thesis sets about to answer three research questions grounded in transcriptional regulation of hepatic genes in the high yielding postpartum dairy cow under negative energy balance (NEB). For this purpose we used ... -
Analysis of putative somatic mutations in 200,000 human exomes
Bennett, Declan (NUI Galway, 2023-09-19)Somatic mutations accumulate throughout life and contribute significantly to disease risk. While research into somatic mutation is well established in cancer, it is only in recent years that investigations into the ... -
Computational approaches to identify and explain sources of error in cancer somatic mutation data
O’Sullivan, Brian (NUI Galway, 2024-04-18)Errors in the identification of somatic mutations in cancer samples can have critical implications in both research and clinical applications. Failure to detect potential variants of interest can lead to missed opportunities ... -
Differences in immunogenicity between cancer mutation signatures shed light on immunoediting
Khehrah, Noor (NUI Galway, 2024-04-15)Immunoediting is a process through which the immune system plays a role in shaping the mutational landscape of cancer and, consequently, in cancer progression. One critical aspect of immunoediting is the phenomenon known ... -
Estimation and analysis of gene expression and alternative splicing: perspectives from development and disease
Korir, Paul Kibet (2014-01-30)The development of high-throughput genomics technologies has contributed substantially to the understanding of gene expression regulation. With the growing appreciation of the importance of alternative splicing, quantitative ... -
Evolutionary Models for the Human Immunodeficiency Virus with Applications to Epitope Prediction and the Natural Selection of Escape Variants
Lacerda, Miguel (2012-02-08)In this thesis, evolutionary models are developed for protein coding sequences of the human immunodeficiency virus (HIV). These models are applied to predict the epitopes targeted by the cell-mediated and humoral arms of ... -
The genomic architecture of nucleolar organiser regions on the short arms of human acrocentric chromosomes
Barreira, Sofia (2015-09-29)Nucleolar Organiser Regions (NORs) are comprised of ribosomal gene (rDNA) arrays and adjacent sequences. Nucleoli, the sites of ribosome biogenesis and key regulators of cellular growth and proliferation, form around NORs. ... -
Investigation of intron coevolution and the autoimmune potential of alternative splicing
Keane, Peter (2016-07-20)Introns are non-coding intergenic sequences that are routinely excised from nascent pre-mRNA transcripts by a process known as splicing. Although they do not contribute directly to the protein-coding sequences of genes, ... -
Investigation of T cell receptor and immunoglobulin repertoire through next generation sequencing data
Yu, Yaxuan (2017-08-08)The diversity of the immunological repertoire has long been a subject of research focus, providing important insights into the adaptive immune system. Rapid developments in next generation sequencing technologies ... -
Novel Insights into Chromatin Structure and Gene Regulation through Integrative Analysis of High Throughput Genomics Data
Nguyen, Thong (2014-01-14)Genetics and epigenetics research has evolved dramatically over the last decade, owing to rapid developments in high-throughput genomics techniques. Analysis of the resulting quantities of data requires advanced computational ... -
Pathogen genomics of methicillin resistant staphylococcus aureus and leishmania
Coughlan, Simone (2017-02-15)Infectious diseases caused by the single-celled eukaryotic parasite Leishmania and the methicillin-resistant Staphylococcus aureus (MRSA) bacterium are major public health problems in many countries. In this thesis, I use ... -
Transcriptome analysis in Hydractinia echinata reveals species-specific and phylum-wide gene loss
Doonan, Liam B. (NUI Galway, 2018-05-04)The advances and subsequent widespread use of next-generation sequencing, in particular transcriptomics, has allowed biologists to approach questions and study many more powerful and previously underappreciated model animals ...