Browsing University of Galway Theses (PhD Theses) by Author "Murphy, Paul"
Now showing items 1-6 of 6
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Carbohydrates as precursors to macrocyclic and iminosugar frameworks
Chadda, Rekha (2017-09-30)Natural products have been perceived as privileged structures in drug discovery based on their evolutionary experience. Chapter 1, explores previous exploitation of this platform by medicinal chemists to identify some ... -
Design and synthesis of macrocycles, peptides and coiled coils with sugar connections
Sweeney, Sinclair (2016-06-09)Migrastatin is a secondary metabolite that is formed from the bacterium Streptomyces platensis. This compound has shown promising anti-metastatic activity by inhibiting tumour cell migration. Published derivatives of this ... -
Hydrogen peroxide and hydrohalic acid mediated synthesis of halogenated benzimidazolequinones and anti-cancer evaluation of benzotriazinones
Sweeney, Martin (NUI Galway, 2019-11-29)Chapter 1 provides a literature review of metal and metal-free oxidative annulations employed to access ring-fused benzimidazoles while highlighting their significance and application towards anti-tumour benzimidazolequinones. ... -
Investigation of various ligand design approaches and synthesis of diverse heterocyclic bioactive compounds
Negi, Arvind (NUI Galway, 2019-09-27)Structure-based design and ligand-based design are one of the most common approaches used to develop new inhibitors against druggable protein targets in various human disorders. Mcl-1 is a protein belongs to Bcl-2 family ... -
Marine biodiscovery from Floridian mangrove forests and Irish waters
Soldatou, Sylvia (2017-08-23)Natural products have been used since ancient times to treat illnesses and terrestrial organisms have been studied extensively from a chemical point of view. Marine organisms, on the other hand are definitely understudied ... -
Part 1: Palladium catalysed deuteration of indoles: Part 2: Development of vovel inhibitors for influenza hemagglutinin
Fitzgerald, Liam (NUI Galway, 2024-04-10)For the first two years of my Ph.D programme, I conducted research under the supervision of Dr. Miriam O’Duill. This research is outlined in Part 1 of this thesis. Following Dr. O.Duill’s appointment at the University ...