Browsing University of Galway Theses (PhD Theses) by Author "Miller, Nicola"
Now showing items 1-6 of 6
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Clinical Applications of Molecular Profiling in Colorectal Cancer
Kheirelseid, Elrasheid Ahmed Hassan (2011-06)Despite developments in diagnosis and treatment, 20% of colorectal cancer (CRC) patients present with metastatic disease and 30% of cases recur after curative surgery. Furthermore, the molecular factors involved in prognosis ... -
Expression Profiling of circulating micro-RNAs in Prostate Cancer
Kelly, Brian Daniel (2013-08-06)Mi(cro)RNAs are small non-coding RNAs whose differential expression in tissue has been implicated in the development and progression of many malignancies, including prostate cancer. The discovery of miRNAs in the blood of ... -
Identification and characterisation of germline variants in an Irish cohort with breast cancer
McVeigh, Úna (NUI Galway, 2020-02-10)Breast cancer is the most common female malignancy worldwide, and the second most common cause of cancer-related deaths in women. Twin studies estimate that up to one third of breast cancers are the result of hereditary ... -
Investigating the impact of genomic profiling on breast cancer risk prediction, treatment and outcome
McVeigh, Terri (2018-02-05)It has, for many years, been acknowledged that “breast cancer” is an umbrella term for many genetically and immunophenotypically distinct malignancies of the breast. Treatment paradigms are shifting in direct response to ... -
MiRNAs as oncologic biomarkers for breast cancer
McDermott, Ailbhe (2014-08-18)Understanding of the molecular complexity underlying breast cancer has greatly advanced in recent years. Distinct phenotypic subtypes have been identified each of which carry prognostic and predictive implications. Despite ... -
Molecular profiling and genomic substratification to personalise therapeutic decision making in cancer
Davey, Matthew (NUI Galway, 2022-08-16)Breast cancer management recognises that the unique genetic expression profiles of each cancer enables substratification into clinically and therapeutically distinct molecular subgroups. There are pragmatic ways of ...