Browsing University of Galway Theses (PhD Theses) by Title
Now showing items 618-637 of 2245
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Effects of hypoxia on the response of the haematopoietic system to radiation-induced DNA damage
(2017-05-09)Preparative regimens using DNA damaging agents such as total body irradiation (TBI) prior to bone marrow transplantation (BMT) have profound deleterious effects on the hematopoietic system including the stromal cells that ... -
Effects of proteasome inhibition on cisplatin induced DNA damage responses in human cells
(2012-02-07)The proteasome is the main site of protein degradation in human cells, and plays a major role in the regulation of cellular processes including cell cycle progression, DNA repair and the DNA damage response. Proteasome ... -
Effects of remote ischaemic preconditioning on vascular and general surgery patients’ outcomes
(NUI Galway, 2017-09-29)Remote ischaemic preconditioning (RIPC) has been suggested as a non-invasive treatment option in many recent studies. The focus of this thesis is to evaluate the possible effect of this on major health problems in vascular ... -
The effects of Vibrio parahaemolyticus on Mitogen Activated Protein Kinase signalling pathways and intestinal epithelial host cell responses
(2013-02-20)Vibrio parahaemolyticus is a gram negative bacterium that is found in marine and estuarine environments. Although found amongst the commensal flora of shellfish, V. parahaemolyticus is a potent human pathogen. Consumption ... -
Efficient path query approaches over distributed linked data
(NUI Galway, 2021-03-18)In the past decade, graphs have become the defacto data model in some of the popular application domains such as bioinformatics, social, and road networks. One of the most used variants of the graph model is the labeled ... -
Elastin-based hydrogel as a treatment for critical limb ischemia, an insight into the glyco-host response
(NUI Galway, 2019-10-01)Critical limb ischemia (CLI) is severe impairment of the microcirculation resulting in inflammation, ischaemic pain, non-healing ulcers and gangrene. Over 20% of patients have no option but to undergo a major limb amputation. ... -
Elastin-like polypeptide mediated proangiogenic and anti-inflammatory gene therapy for critical limb ischemia
(2014-12-17)Critical limb ischemia is a major clinical problem. Despite rigorous treatment regimes, there has been modest success in reducing the rate of amputations in these patients. Reduced level of blood flow and enhanced inflammation ... -
Elastin-like recombinamers-based hydrogel modulates the post-ischemic remodelling in a clinically-relevant model of myocardial infarction
(NUI Galway, 2019-04-17)Myocardial infarction (MI) belongs to the family of cardiovascular diseases and represents the primary cause of worldwide mortality. Despite the promising results achieved in both small and large animal studies, recent ... -
Electrical impedance tomography for static lesion detection and identification in the brain
(NUI Galway, 2020-08-20)There is a clinical need for a novel approach to the detection of brain haemorrhage and clots. Such static lesions are characteristic of important conditions such as stroke, and traumatic brain injury. In these conditions ... -
Electromagnetic modelling and experimentation for the development of a novel microwave thermal ablation therapy for adrenal tumours
(NUI Galway, 2021-11-29)Primary Aldosteronism is the main cause of the secondary hypertension, due to the abnormal functioning of the adrenal glands. Adreno-cortical adenomas and bilateral hyperplasia are the most common causes of the abnormal ... -
Electromagnetic modelling and signal processing algorithms for a microwave-tomography-based medical device prototype to monitor osteoporosis
(NUI Galway, 2021-12-12)Osteoporosis, characterised as low bone mass, causes continuous systematic deterioration of the trabecular bone structure and leads to bone fragility and fractures. Current clinical practices widely employ dual-energy X-ray ... -
Electrophysiological Activity During Stimulus Class Formation
(2012-02-15)The current project attempted to isolate patterns of electrophysiological activity that correlate with stimulus equivalence by examining the frequency spectra of simultaneous electroencephalographic (EEG) activity. This ... -
Elucidating levels and pathways of human exposure in Ireland to POP-BFRs and PFOS (ELEVATE)
(NUI Galway, 2019-12-17)BFRs such as hexabromocyclododecane (HBCDD) and polybrominated diphenyl ethers (PBDEs) were used as flame retardants (FRs) in soft furnishings, building insulation foams, electronic and electrical goods. Perfluoroalkyl ... -
Elucidation of the role of the glutamate decarboxylase system and the gamma-aminobutyric acid shunt pathway in the stress response of Listeria monocytogenes
(2014-07-22)The foodborne pathogen Listeria monocytogenes is the causative agent of listeriosis in humans and other animals. This disease can have a fatality rate of up to 30% in infected patients and leads to spontaneous abortion in ... -
Emanuel Carnevali's cultural translation: an Italian in Modernist America
(2016-02-09)The thesis investigates translingual writing – that is, writing in a language which is not the native one – at the intersection between culture, identity, and translation. The focus is here on Italian American writer Emanuel ... -
Embattled families: Parents’ experiences of child to parent violence and abuse and of the non-violent resistance intervention
(NUI Galway, 2024-04-17)Despite extensive activity in the field of domestic violence in recent decades, the matter of child to parent violence and abuse has been largely ignored in policy, practice and research until relatively recently. While ... -
Embedded Reddit - An investigation into improved information extraction from Reddit through word embeddings
(NUI Galway, 2020-12-31)Social media has increasingly become a de facto source of information for people seeking to inform themselves on current events. Traditionally there has always been a centralised source such as news-papers or news ... -
Emergence in hybrid adaptive multi-agent systems
(NUI Galway, 2021-03-10)This thesis investigates a number of hybrid adaptive strategies to drive multi-agent systems from initial states of disorder towards consensus or favourable configurations. The dynamics of the agents and their communicative ... -
Emerging new product development methodology for the automobile industry
(2014-07-21)New competitive pressures are unsettling traditional carmakers. These include: new consumer groups in emerging markets; zero emission requirements of existing customers; new competitors from emerging markets; and increasing ... -
Emotions & social change in Ireland: Exploring habitus shift in liquid modernity
(2013-10-17)Drawing on insights from a range of disciplines, including philosophy, psychology, history, politics, but particularly sociology and sociological theory, this thesis explores the relationship between emotions and social ...