Browsing University of Galway Theses (PhD Theses) by Title
Now showing items 251-270 of 2245
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Characterisation of bovine pericardium and alternative treatments for its application as biomaterial
(NUI Galway, 2020-04-09)Bovine pericardium is an extensively used biomaterial utilised in a wide range of biomedical devices such as bioprosthetic heart valves. The characterisation techniques employed for the analysis of bovine pericardium and ... -
Characterisation of core histone sequences and nuclear mobility using a reproducible research approach
(2017-09-19)Chromatin is a dynamic complex that controls access to genetic information by undergoing structural reconfigurations. Understanding this dynamic can provide insights into the biological implications of chromatin ... -
Characterisation of histone variants in the cnidarian Hydractinia
(NUI Galway, 2019-02-21)Hydractinia is a marine hydrozoan cnidarian that has been a model organism for developmental biology for over a century. Very few studies have been carried out on chromatin biology in cnidarians. To date, there is no ... -
Characterisation of human nucleolar organisers located in previously uncharted regions of the human genome
(NUI Galway, 2019-01-18)The nucleolus is a large, sub-nuclear domain and the site of ribosome biogenesis. Nucleoli form around chromosomal loci called ‘nucleolar organiser regions (NORs) located on the short arms of the human acrocentric ... -
Characterisation of novel ATM-interacting factors involved in double-strand break repair
(2012-10-22)Ataxia-telangiectasia (A-T) is a rare human disease characterized by cerebellar degeneration, immune system defects and cancer predisposition. The disease has been the subject of intense scientific scrutiny, particularly ... -
Characterisation of novel Histone H3 RAD9 mutants defective in the DNA damage response in Saccharomyces cerevisiae
(2013-02-28)The DNA damage response (DDR) is a signal transduction cascade, which regulates cell cycle progression, gene transcription and DNA repair. Histones also play a vital role in the activation of the DDR and have been shown ... -
Characterisation of rotationally moulded polymer liners for low permeability cryogenic applications in composite overwrapped pressure vessels
(2016-09-20)Composite overwrapped pressure vessels (COPVs) have become a critical component in satellite and space applications due to their ability to store highly permeating fuels at high pressures and under cryogenic conditions. ... -
Characterisation of sex differences in behavioural domains and antidepressant response in two rat models of depression
(NUI Galway, 2018-10-17)Although the rate of depression is known to be almost twice as high in women compared to men, most evaluation of antidepressant efficacy involved only males until the early 1990s. In pre-clinical depression research male ... -
Characterisation of the cellular responses to CDC7 inhibition in breast-derived human cells
(2017-10-06)CDC7 plays a role in DNA replication initiation and cell cycle regulation. Inhibition of CDC7 kinase by siRNA triggers a p53-independent apoptotic cell death in cancer cells but not in human fibroblast suggesting this ... -
Characterisation of the molecular and functional changes exerted on human bone marrow mesenchymal stem cells by prostate cancer cells
(2016-07-01)Mesenchymal stem cells (MSCs) are a heterogenous population of multipotent cells that are capable of differentiating into osteocytes, chondrocytes and adipocytes. MSCs reside in various areas such as the bone marrow, ... -
Characterisation of three zinc finger proteins ZC3H8, ZC3H11A and ZC3H14, identified as new partners of ATM, the central regulator of biological response to DNA double strand breaks
(NUI Galway, 2019-12-16)The integrity of our genome is very important therefore, our cells have developed efficient DNA repair mechanisms to control this integrity and avoid mutations. Although the DNA double strand break response pathway is ... -
Characterisation of triple negative breast carcinoma and identification of the value of immunohistochemical markers and stromal tumour infiltrating lymphocytes
(NUI Galway, 2017-10)Breast cancer is a complex disease that encompasses multiple molecular subtypes that have different clinical behavior. The behavior can be influenced by both the characteristics of the cancer cells as well as the surrounding ... -
Characterisation of UVA-induced DNA damage responses in human skin cells
(2013-09-30)Accumulating evidence indicates that exposure to long-wavelength ultraviolet A (UVA) radiation (315-400 nm), which accounts for >95% of solar UV radiation reaching the earth's surface, is a significant risk factor for the ... -
Characterising bases of pure difference ideals
(NUI Galway, 2020-09-10)In this thesis, we study the basis sets of pure difference ideals, that is, ideals that are generated by differences of monic monomials. We examine the action of the hyperoctahedral group on the defining ideal of the Segre ... -
Characterising occupational exposure to glyphosate among amenity horticulturists
(NUI Galway, 2018-12-19)A dearth of knowledge exists regarding occupational glyphosate exposures among amenity horticulturalists. Glyphosate is the highest volume herbicide used globally, and has recently been classified by the International ... -
Characterising the geochemistry of the natural environment using compositional data analysis
(NUI Galway, 2021-05-31)The geochemistry of the natural environment (e.g. soils, streams, sediments and groundwater) is representative of the source(s) from which these materials are derived. In fact, a geochemical dataset is essentially a ... -
Characterization of a Crustal Transition Zone in Northern Tibet using Magnetotelluric Modelling
(2013-10-25)The overall objective of the final phase of the INDEPTH (International Deep Profiling of Tibet and Himalaya) project has been to develop a better understanding of the structure and evolution of the northern margins of the ... -
Characterization of a novel antimicrobial agent inspired by peroxidase-catalyzed systems
(2017-09-29)The phenomenon of antibiotic resistance is expanding and the threat regarding our future ability to combat infection is increasing. Thus, key challenges for society and for researchers are to address microbial drug resistance ... -
Characterization of a novel cell death-inducing protein complex assembled in response to stress
(NUI Galway, 2021-01-26)Pro-caspase-8 is the apical caspase in the extrinsic apoptosis which is initiated by the external stimulation of certain death receptors. Pro-caspase-8 is synthesised as an inactive zymogen, which must be cleaved to reach ... -
Characterization of a novel zebrafish model of arrhythmogenic right ventricular cardiomyopathy
(NUI Galway, 2018-12-14)Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is a congenital heart disorder characterized by replacement of the ventricular myocardium with fibrofatty tissue. The majority of cases are due to mutations in genes ...