Browsing University of Galway Theses (PhD Theses) by Title
Now showing items 647-666 of 2245
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Endocannabinoid modulation of TLR4-induced neuroinflammation: implications for autism spectrum disorders
(2014-07-07)Neuroinflammation is a key component of various neurological diseases including Alzheimer's disease, Parkinson's disease, multiple sclerosis and psychiatric and neurodevelopmental disorders such as depression and autism. ... -
Endocannabinoid regulation of neuroinflammatory responses following acute systemic viral (TLR3) and bacterial (TLR4) infection
(2015-10-14)Toll like receptors (TLRs) are key players in host defence, homeostasis and response to injury. However, uncontrolled and aberrant TLR activation has been proposed to trigger the onset of certain neurodegenerative disorders ... -
Endoplasmic Reticulum Stress as a Component of Demyelination in Animal Models of Multiple Sclerosis
(2012-12-19)Endoplasmic reticulum (ER) stress is a homeostatic signalling pathway, linked to many neurological diseases including multiple sclerosis (MS), which can lead to cell death when prolonged. Increasing evidence suggests that ... -
Endoplasmic reticulum stress signalling in myelination
(2017-12-07)Demyelinating conditions such as multiple sclerosis have a continued unmet need for remyelinating therapies. Myelin is a multi-lamellar membrane structure made by oligodendrocyte progenitor cells (OPCs) that is critical ... -
Energy biographies: Exploring the intersections between lives, practices and contexts
(2017-02)Individual consumption and behaviour change has become a key area of attention in European and Irish sustainable development policy. To date, policy approaches to consumption have been informed by individualised models of ... -
An energy efficient spectrum sensing scheme for the cognitive radio based internet of things
(NUI Galway, 2020-07-29)Spectrum sensing in a cognitive radio network involves detecting when a primary user vacates their licensed spectrum to enable secondary users to broadcast on the same band. Accurately sensing the absence of the primary ... -
Energy recovery and pathogen inactivation with dry co-digestion of food waste and pig manure
(NUI Galway, 2019-03-14)Anaerobic digestion is one of the best available technologies for food waste (FW) and pig manure (PM) management by producing methane-rich biogas. However, mono digestion of FW or PM is easily inhibited by high volatile ... -
Enhancing knowledge graph completion models and selected biological applications
(NUI Galway, 2020-06-18)Knowledge completion is the task of extending knowledge graphs to enhance the quality of systems relying on them. In recent years, various knowledge completion techniques were developed to model knowledge graphs using ... -
Enhancing spectrum sensing performance for the cognitive radio based internet of things
(NUI Galway, 2021-12-26)In cognitive radio based internet of things (CR-IoT) networks spectrum sensing and decision making processes to determine whether the primary user (PU) signal is present or absent in the network are very important and ... -
Enhancing the bioavailability of active pharmaceutical ingredients through cocrystallization and coamorphization
(NUI Galway, 2019-12-19)During drug research and development, improving the solubility of poorly water soluble drugs without chemically modifying the drug molecule is one of the biggest challenges for the pharmaceutical industry. Most medicines ... -
Enhancing the efficacy and therapeutic potential of human mesenchymal stromal cells (hMSCs) in clinically relevant sepsis models
(NUI Galway, 2022-08-30)Rationale: Sepsis is a systemic inflammatory process produced by the reaction of the immune system against a pathogen. This inflammatory process produces tissue damage leading into vital organ malfunction and, if not ... -
Enhancing the immunomodulatory capacity and therapeutic potential of mesenchymal stromal cell-derived small extracellular vesicles through cytokine licensing
(NUI Galway, 2023-09-12)The immunomodulatory capacity of mesenchymal stromal cells (MSCs) is well established, and is being explored as a cellular therapy for the treatment of various inflammatory-based conditions. In recent years, the role of ... -
Enhancing the immunomodulatory efficacy of allogeneic mesenchymal stromal cells through pro-inflammatory cytokine licensing
(NUI Galway, 2024-04-17)The therapeutic efficacy and immunomodulatory potential of mesenchymal stromal cells (MSCs) is well established. MSCs have been employed as cellular therapies to treat various inflammatory-based conditions. MSC potency can ... -
Enhancing the situational awareness of the active distribution network
(NUI Galway, 2022-06-21)Power distribution system operation has become increasingly complex with the large-scale integration of Distributed Energy Resources (DERs). This has led to a paradigm shift in the operation and planning of the power ... -
Enhancing trust in detecting security threats using machine learning approaches and its application in the Internet of Things
(NUI Galway, 2022-12-13)Identifying network attacks is a very crucial task for network security. The increasing amount of network devices is creating a massive amount of data and opening new security vulnerabilities that malicious users can ... -
Enhancing willingness to whistleblow internally: The role of leaders and work culture
(NUI Galway, 2021-03-30)Whistleblowing research shows that leaders play an essential role in steering ethical behaviour and work culture. This thesis investigates the factors that enhance employee willingness to internal speak up and how leadership ... -
Enterprise education in post-primary schools: An exploration of the antecedent and contextual factors that impact on successful provision
(NUI Galway, 2020-04-30)Enterprise education is universally lauded as a means to enabling an enterprising capacity in young citizens who benefit the local and national economy while also being one of the eight European Union key competences. ... -
Entity summarisation for entity-centric publish/subscribe systems
(NUI Galway, 2021-12-21)The Internet of Things (IoT) has contributed to physical devices generating entity-centric data (e.g. smart buildings). To bridge the gap between the devices’ data and the users’ interests, Publish/Subscribe systems (Pub/Sub) ... -
Entrepreneurial networking and the development of marketing capabilities in SMEs. A study of Irish entrepreneurs
(2016-09-16)It is widely accepted across the marketing, entrepreneurship and strategic management literatures that relationships and networks are instrumental for the growth and performance of SMEs. In particular, in the entrepreneurial ... -
Entrepreneurial self-efficacy (ESE): a business model approach
(2016-04-07)Researchers of entrepreneurship lack a general, yet distinct, conceptual framework that both describes how entrepreneurial action occurs and predicts who does it. Some scholars have noted that the emerging concept of ...