Browsing University of Galway Theses (PhD Theses) by Title
Now showing items 991-1010 of 2245
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Human stem cell modeling for amyotrophic lateral sclerosis
(NUI Galway, 2022-09-28)Amyotrophic lateral sclerosis (ALS) is a fatal and progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons (MNs). Most ALS cases are sporadic, with no family history or known genetic ... -
Human stem cell modelling for heart disease of long QT syndrome
(NUI Galway, 2022-04-29)Sudden cardiac death (SCD) in otherwise healthy young people is a public health priority. Long QT syndrome (LQTS) is the commonest life-threatening cardiac arrhythmia contributing to SCD under 40 years old with an estimated ... -
Human trafficking and China: Past and present
(2014-06)The idea of human trafficking as a new and distinct problem, a modern form of slavery that entraps individuals without agency in their own countries and abroad, is a common perception that has popularised the usage of the ... -
A human-centered design of a connected health system for older adults
(2017-08-15)The work outlined in this thesis explores the design of Connected Health devices, analyses the user characteristics of older adults and suggests a design methodology which was then applied to the design of two elements ... -
Hurdles for computationalism: The many difficulties facing a computationalist theory of phenomenal consciousness
(NUI Galway, 2023-11-20)There are several things that might be called ‘computationalism’. The one most central to the philosophy of mind is a theory that attempts to answer what Chalmers calls the ‘hard problem’ of consciousness: how can it ... -
A Hybrid Framework for Querying Linked Data Dynamically
(2012-09-28)As of today, the Web has evolved to become the largest collection of information made available by mankind. Researchers and developers are continuously working on transforming this loosely connected data collection into ... -
Hybrid simulation of ethernet based intra-vehicle networks
(2016-12-09)As Advanced Driver Assist Systems (ADAS) increase in complexity, it becomes essential to be able to rapidly prototype and test these systems in a reproducible and reliable way. This work explores the problem of simulating ... -
Hybrid systems modelling aided by machine learning with applications in healthcare
(NUI Galway, 2018-03)Recent trends towards data-driven methods may require a substantial rethinking of the process of developing simulation models. For instance, Machine Learning (ML) has demonstrated great potentials for constructing new ... -
Hydrogen peroxide and hydrohalic acid mediated synthesis of halogenated benzimidazolequinones and anti-cancer evaluation of benzotriazinones
(NUI Galway, 2019-11-29)Chapter 1 provides a literature review of metal and metal-free oxidative annulations employed to access ring-fused benzimidazoles while highlighting their significance and application towards anti-tumour benzimidazolequinones. ... -
Hydrogeophysics of coastal aquifers - geophysical applications to the assessment of groundwater properties in coastal gravel and karst aquifers
(2017-05-19)Airborne, terrestrial and marine geophysics have been employed to examine coastal zone hydrogeology in two very different aquifer types in Ireland. Modelling of regional airborne electromagnetic data informed by ground-based ... -
Hydrolysis, methanogenesis and bioprocess performance during low-temperature anaerobic digestion of dilute wastewater
(2015-04-28)Anaerobic digestion (AD) technologies represent sustainable and appropriate systems for the treatment of organic wastewaters. Lettinga et al (1987) stated, "A satisfactory application to raw domestic sewage would represent ... -
Hygroscopicity of marine aerosol: Closure, long term observation and cloud condensation potential
(NUI Galway, 2021-09-18)Marine aerosols have a profound impact on the global climate system by scattering solar radiation and serving as seeds for cloud formation. However, the marine aerosols in current models are still poorly represented and ... -
Hypertextualized Virtual Environments: Dual-Mode User Interface Design
(2011-06-03)This thesis develops a novel strategy for accessing Hypertextualized Virtual Environments (HiVEs), integrated information spaces where symbolic (hypertext) and visual (3D graphics) data are simultaneously available and ... -
Hypoxia activates the PTHrP – Zfp521 – MEF2C pathway to attenuate hypertrophy in mesenchymal stem cell derived cartilage
(2016-04-22)The treatment of cartilage defects remains an unmet medical need as the current treatment options are currently sub-optimal as the most common treatment options; microfracture and autologous chondrocyte implantation (ACI) ... -
“I have loads of cool ideas…” A study of the nature of young children’s autonomous participation in a strategic policy development process
(NUI Galway, 2021-12-21)Children’s participation is increasingly recognised as informing the development of policies and strategies that are concerned with service provision for children and families. Creating space for children to express their ... -
'I'm not going to be able to leave'; The impact of belonging to the Irish farming community on university students' life experiences and transitions to adulthood
(2014-02-10)Despite extensive research into family farming culture little attention has been paid to young people raised in this community who do not become full-time farmers. This thesis explores the childhood experiences of university ... -
I-Ulysses: poetry in motion. An educational virtual reality guide to the unfolding events of the ‘Wandering Rocks’ chapter of Joyce’s Ulysses.
(2016-01-29)A spatial and temporal virtual reality experience, guiding the user through the unfolding events of the ‘Wandering Rocks’ chapter of James Joyce’s Ulysses. This is an educational tool intended to help the user understand ... -
Identification and analysis of polymorphisms in miRNA genes and associated targets in Bos taurus and Bos primigenius for genomic selection in cattle
(2017-02-21)Cattle production is of high economic importance to agriculture in Ireland. For more than a decade, significant effort focused on the improvement of the selection of economically important traits in beef and dairy breeds. ... -
Identification and characterisation of germline variants in an Irish cohort with breast cancer
(NUI Galway, 2020-02-10)Breast cancer is the most common female malignancy worldwide, and the second most common cause of cancer-related deaths in women. Twin studies estimate that up to one third of breast cancers are the result of hereditary ... -
Identification and characterisation of novel glycan-binding bacterial adhesins encoded by the human gut microbial metagenome
(2017-03-24)Although there have been an increasing number of scientific publications describing the adherence of gut bacteria to components of the human intestinal mucosa, very little is known about the surface molecules mediating ...