Browsing University of Galway Theses by Author "Murphy, Paul V."
Now showing items 1-19 of 19
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The anomerisation of glycosidic linkages
Farrell, Mark (2014-04-07)This thesis deals with the anomerisation of glycosidic linkages using TiCl4 and SnCl4. Methods involving the Lewis acid induced anomerisations of glycosides have been published over the past decade, however this methodology ... -
The anomerisation of glycosyl thiols and synthesis of multivalent GlcNAc and GalNAc glycoclusters
O'Sullivan, Shane (2015-04-29)There are several published procedures available for the synthesis of b-thiopyranoses such as gluco- or galacto-pyranoses. Given the ease with which one can access such b -thiopyranoses, the development of a reproducible ... -
Carbohydrates in the synthesis of macrocycles and glycoclusters
Fox, Karen A. (NUI Galway, 2019-01-28)This thesis deals with efforts to generate new bioactive organic compounds. The main focus has been on the use of carbohydrate building blocks for synthesis of both macrocyclic compounds and glycoclusters for biological ... -
Design and synthesis of novel constrained glycomimetics as inhibitors of galectins and galactosidases
Hever, Eoin (NUI Galway, 2023-10-10)Chapter 1 gives a brief introduction to carbohydrate structure, discussing factors influencing reactivity and conformation, such as the anomeric and exo-anomeric effect. Chapter 1 mentions methods of structural analysis ... -
Design, synthesis and evaluation of glycomimetics as galectin inhibitors
Dhara, Ashis (NUI Galway, 2024-03-11)Chapter-1: This chapter begins with a short review on carbohydrates and their structure and then summarises some highlights from the last two decades of research on developing carbohydrate-based drug candidates. Included ... -
Enzymes in the World of Computational Chemistry - Computational Studies on Structures, Dynamics, Mechanisms, and Specificity of Five Biologically Important Enzymes
Tian, Boxue (2012-10-30)The thesis demonstrates computational chemical methodology applied to some biologically important enzymes. Five enzymes have been studied, i.e. sortase A (SrtA), 2-Methyl-3-hydroxypyridine-5-carboxylic acid oxygenase ... -
Mechanistic and kinetic study on the anomerisation reaction and application in pharmaceutical research
Holland, Trish (NUI Galway, 2024-01-08)It is becoming increasingly apparent that carbohydrate-based pharmaceutically active compounds (PACs) play a key role in pharmaceutical advancement. Many new carbohydrate-based PACs have recently been developed with a ... -
Metal-based glycoconjugates as molecular sensors for lectins and anti-adhesives
Wojtczak, Karolina (NUI Galway, 2024-04-05)The anti-microbial resistance crisis has been inexorably developing at ever more alarming levels in the 21st century. The WHO regularly updates a list of bacterial and fungal critical priority pathogens for which new ... -
Studies in anomerisation of glycosyl thiols and glycosides
Doyle, Lisa M. (NUI Galway, 2018-06-29)The stereoselective generation of 1,2-cis linkages continues to be a substantial challenge in carbohydrate chemistry today. Lewis acid-promoted anomerisation of 1,2-trans linkages offers a facile method to generate 1,2-cis ... -
Studies of Lewis acid promoted anomerisation reactions
Meany, Fiach B. (NUI Galway, 2023-01-23)The stereoselective synthesis of the glycosidic bond still remains a challenge for the synthetic carbohydrate chemist. Lewis acid promoted anomerisation offers a useful means of generating 1,2-cis glycosides from their ... -
A study in carbohydrate chemistry: From anomerisation to synthesis of glycoclusters based on neoglycopeptides
Di Salvo, Claudia (NUI Galway, 2018-08-08)1,2-cis aminoglycosides are considered difficult to prepare in a highly stereoselective manner. Some strategies have been developed to date including the preparation of 2-azido, 2-benzylidine and 2,3-oxazolidinone glycosyl ... -
A study of factors influencing anomerisation reactions
Kerins, Louise (2016-07-18)This thesis involves an investigation into the anomerisation reaction and strategies by which the reaction can potentially be improved and provide a greater understanding of factors influencing the reaction. There has been ... -
Study of silyl protecting groups in anomerisation reactions: Total synthesis of a glycolipid from Plakortis simplex and its mimetics
Roux, Amélie (NUI Galway, 2019-02-04)This thesis deals with anomerisation, which is, in other words, epimerisation at the anomeric centre, usually interpreted as being from the equatorial to the axial anomer. An objective was to enhance the knowledge of this ... -
Synthesis and evaluation of glycomimetic inhibitors of infectious diseases
Byrne, Syl (NUI Galway, 2023-01-04)Sialic acids are a family of 9-carbon α-keto acid monosaccharides. Sialic acids are critical factors in various biological events, which will be discussed over the course of this thesis. Chapter 1 provides a literature ... -
Synthesis of Iminosugar C-Glycosides via Tandem Allylic Azide Rearrangement - Huisgen Cycloaddition
Moynihan, Lorna (2013-12-16)Iminosugars are naturally occurring polyhydroxylated alkaloids. These natural mimics of carbohydrates have found clinical use with their biological activity mainly attributed to their inhibition of glycoprocessing enzymes. ... -
Synthesis of novel glycolipids and investigation into the anomerisation of selenium glycosides
McDonagh, Anthony W. (2016-07-14)The first section of this thesis describes the synthesis of novel glycosphingolipids with an α-triazole at the anomeric carbon. Glycosphingolipids are amphiphilic molecules containing a carbohydrate head glycosidically ... -
Synthesis of S-glycolipids and peptidomimetics
O'Reilly, Ciaran (2011-08-19)Chapters one and two of this thesis describe the synthesis of two novel glycosphingolipid derivatives. Glycosphingolipids are amphiphilic molecules consisting of a carbohydrate head group glycosidically linked to a sphingoid ... -
Synthesis of tumour cell migration inhibitors
Farrell, Caitriona (2012-09-17)Chapter one and two of this thesis describe the synthesis of novel migrastatin derivatives. Migrastatin is a fourteen-membered macrocycle isolated by Japanese researchers from the Streptomyces platensis. It has been shown ... -
Treatment of dairy soiled water using an aerobic woodchip filter and a sand filter
Ruane, Eimear M (2012-05-04)The milking process produces dairy soiled water (DSW) that contains variable concentrations of nutrients. The most common method of disposal is by application to land. However, this practice can result in the pollution ...