Browsing University of Galway Theses by Author "Joshi, Lokesh"
Now showing items 1-13 of 13
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Development and characterisation of recognition molecules for the specific identification of non-human glycans
Sharma, Shashank (2015-01-26)Glycosylation is an enzymatic process through which glycans attach to proteins, lipids and other organic molecules with huge structural diversity. This is a common post-translational modification found on proteins and cell ... -
Exploring the role of glycosylation in vascular biology, immunology,and stem cell biology
Gill, Satbir Kaur (2016-09-30)Carbohydrates are important modulators in various biological and physiological processes. They are present ubiquitously and coat all cells, forming the glycocalyx of the cell. Glycosylation, a type of post-translational ... -
Fractionation of whey protein glycosylation and assessment of prebiotic and immunomodulation bioactivities for valorisation
Asadi Shehni, Akram (NUI Galway, 2021-03-15)Functional foods are defined as food components that, in addition to their nutritional value, improve human health and/or decrease the risk of diseases. Probiotics, ingested live beneficial bacteria, and prebiotics, the ... -
Generation of recombinant anti-N-glycolylneuraminic acid (Neu5Gc) scFv and its applications for detection and quantitation of Neu5Gc
Sharma, Rajesh Kumar (2016-05-12)Sialic acids are a family of 9 carbon α-keto acid monosaccharides. Owing to their terminal position on glycans, sialic acids are involved in cell adhesion and recognition events, host pathogen interactions, immune regulation ... -
Glycobiology of commensal bacteria with emphasis on cell surface adhesins and exopolysaccharides
Houeix, Benoit (2014-09-25)The human gastro-intestinal tract (GIT) is an elaborate ecosystem specific to an individual and his physiological stage that involves inter- and intra-relationships between the bacteria composing the microbiota and between ... -
Identification and characterisation of novel glycan-binding bacterial adhesins encoded by the human gut microbial metagenome
Agbavwe, Christy (2017-03-24)Although there have been an increasing number of scientific publications describing the adherence of gut bacteria to components of the human intestinal mucosa, very little is known about the surface molecules mediating ... -
The influence of milk oligosaccharides on host-commensal interactions in the GI tract
Kavanaugh, Devon (2013-11)This thesis sets out to explore the influence of milk oligosaccharides on the colonisation of the intestinal microflora and their potential downstream impact upon components of the gastrointestinal tract. Milk oligosaccharides ... -
Mining milk for factors which modulate host-microbial interactions in vitro
Quinn, Erinn Marie (NUI Galway, 2021-02-03)Human milk oligosaccharides (HMO) have been reported to increase the adhesion of Bifidobacterium longum subsp. infantis ATCC 15697 (B. infantis ATCC 15697) to human colonic adenocarcinoma, HT-29 cells. In this thesis, ... -
Multiple myeloma: The role of glycosylation in disease development and progression.
Glavey, Siobhan (2017-09-09)Multiple myeloma (MM) is a clonal plasma cell disorder that is characterized by skeletal destruction, renal failure, anaemia and hypercalcaemia. MM cells are intimately associated with the bone marrow microenvironment, ... -
Novel strategies for exploitation of milk glycoproteins for food ingredient applications
Feeney, Shane (NUI Galway, 2019-08-02)This thesis sets out to explore the potential bioactivities associated with the bovine milk proteome with a view to improving our understanding of the roles bovine milk proteins may play in human health promotion. The ... -
A systems biology frame work for integrating and analysing the functional role of glycosylation on immune response
Oommen, Anup (NUI Galway, 2019-04-23)Reproducing the systems biology efforts established across areas of cell biology such as integrating biological networks with omic datasets and subjecting it to modelling analysis for studying the functional involvement ... -
Targeting the glycome of major milk proteins
O'Riordan, Noelle (2016-10-20)The objectives of this thesis were to 1) explore the glycosylation of major bovine milk proteins, 2) investigate the effect of lactational stage on glycan structures and 3) examine how these documented changes may influence ... -
Targeting the glycome of the milk fat globule membrane for anti-infective properties
Ross, Sarah (2016-10-21)This thesis sets out to explore the potential bioactivities of bovine milk fat globule membrane (MFGM) to enhance our understanding of the roles bovine milk glycoconjugates may play in humans and to contribute towards ...