Browsing School of Natural Sciences by Author "Gorman, Adrienne"
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Nerve growth factor-mediated inhibition of apoptosis post-caspase activation is due to removal of active caspase-3 in a lysosome-dependent manner
Carleton, Laura A.; Doyle, Karen M.; Samali, Afshin; Gorman, Adrienne; Mnich, Katarzyna; Kavanagh, Edel T. (Nature Publishing Group, 2014-05-01)Nerve growth factor (NGF) is well characterised as an important pro-survival factor in neuronal cells that can inhibit apoptotic cell death upstream of mitochondrial outer membrane permeabilisation. Here we addressed the ... -
Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling
Gorman, Adrienne (Wiley, 2008-06-27)Neuronal cell death plays a role in many chronic neurodegenerative diseases with the loss of particular subsets of neurons. The loss of the neurons occurs during a period of many years, which can make the mode(s) of cell ... -
Neurotrophins and B-cell malignancies
Gorman, Adrienne; Hillis, Jennifer; O'Dwyer, Michael (Springer Verlag, 2015-09-23)Neurotrophins and their receptors act as important proliferative and pro-survival factors in a variety of cell types. Neurotrophins are produced by multiple cell types in both pro and mature forms, and can act in an autocrine ...