Browsing College of Science by Author "MacFhionnghaile, Pól"
Now showing items 1-5 of 5
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Effects of ball-milling and cryomilling on sulfamerazine polymorphs: A quantitative study
MacFhionnghaile, Pól; Hu, Yun; Gniado, Katarzyna; Curran, Sinead; McArdle, Patrick; Erxleben, Andrea (Elsevier, 2014-04-11)The effects of ball-milling and cryomilling on sulfamerazine forms I and II (SMZ FI, FII) were investigated using X-ray powder diffraction, infrared and near-infrared (NIR) spectroscopy. Cryomilling resulted in a complete ... -
Formation, physical stability, and quantification of process-induced disorder in cryomilled samples of a model polymorphic drug
Hu, Yun; MacFhionnghaile, Pól; Caron, Vincent; Tajber, Lidia; Healy, Anne Marie; Erxleben, Andrea; McArdle, Patrick (Elsevier, 2012-10-09)The formation and physical stability of amorphous sulfathiazole obtained from polymorphic forms I and III by cryomilling was investigated by X-ray powder diffraction (XRPD) and near-infrared (NIR) spectroscopy. Principal ... -
Investigation of the formation of drug-drug cocrystals and coamorphous systems of the antidiabetic drug gliclazide
Aljohani, Marwah; MacFhionnghaile, Pól; McArdle, Patrick; Erxleben, Andrea (Elsevier, 2019-02-23)The antidiabetic drug gliclazide (GLZ) has a slow absorption rate and a low bioavailability due to its poor solubility. GLZ is often prescribed along with an antihypertensive, as many diabetic patients have coexistent ... -
The natural bile acid surfactant sodium taurocholate (NaTC) as a coformer in coamorphous systems: Enhanced physical stability and dissolution behavior of coamorphous drug-NaTc systems
Gniado, Katarzyna; MacFhionnghaile, Pól; McArdle, Patrick; Erxleben, Andrea (Elsevier, 2018-10-28)The amorphization of 18 different drugs on milling with one mole equivalent sodium taurocholate (NaTC) was investigated. In all cases the X-ray powder pattern showed an amorphous halo after milling at room temperature or ... -
Spontaneous solid-state cocrystallization of caffeine and urea
MacFhionnghaile, Pól; Crowley, Clare M.; McArdle, Patrick; Erxleben, Andrea (American Chemical Society, 2020-01-09)The cocrystallization of caffeine and urea was monitored and analyzed using infrared spectroscopy, Raman microscopy, scanning electron microscopy, differential scanning calorimetry, and X-ray diffraction. The caffeine-urea ...