Browsing College of Science by Author "Galway University Foundation"
Now showing items 1-6 of 6
-
Effects of nerve bundle geometry on neurotrauma evaluation
Cinelli, Ilaria; Destrade, Michel; McHugh, Peter; Duffy, Maeve (Wiley, 2018-06-16)ObjectiveWe confirm that alteration of a neuron structure can induce abnormalities in signal propagation for nervous systems, as observed in brain damage. Here, we investigate the effects of geometrical changes and damage ... -
Electro-mechanical response of a 3D nerve bundle model to mechanical loads leading to axonal injury
Cinelli, Ilaria; Destrade, Michel; Duffy, Maeve; McHugh, Peter (Wiley, 2017-11-21)Traumatic brain injuries and damage are major causes of death and disability. We propose a 3D fully coupled electro-mechanical model of a nerve bundle to investigate the electrophysiological impairments due to trauma at ... -
Electrothermal equivalent three-dimensional finite-element model of a single neuron
Cinelli, Ilaria; Destrade, Michel; Duffy, Maeve; McHugh, Peter (Institute of Electrical and Electronics Engineers, 2017-09-14)Objective: We propose a novel approach for modelling the interdependence of electrical and mechanical phenomena in nervous cells, by using electrothermal equivalences in finite element (FE) analysis so that existing ... -
Head-to-nerve analysis of electromechanical impairments of diffuse axonal injury
Cinelli, Ilaria; Destrade, Michel; McHugh, Peter; Trotta, Antonia; Gilchrist, Michael; Duffy, Maeve (Springer, 2018-11-14)The aim was to investigate mechanical and functional failure of diffuse axonal injury (DAI) in nerve bundles following frontal head impacts, by finite element simulations. Anatomical changes following traumatic brain injury ... -
Label free ultra-sensitive imaging with sub-diffraction spatial resolution
Alexandrov, Sergey; Das, Nandan; McGrath, James; Owens, Peter; Sheppard, Colin J. R.; Boccafoschi, Francesca; Giannini, Cinzia; Sibillano, Teresa; Subhash, Hrebesh; Leahy, Martin (IEEE, 2019-07-09)In this paper, we show a new way to break the resolution limit and dramatically improve sensitivity to structural changes. To realize it we developed a novel label free contrast mechanism, based on the spectral encoding ... -
Spatial frequency domain correlation mapping optical coherence tomography for nanoscale structural characterization
Alexandrov, Sergey; McNamara, Paul M.; Das, Nandan; Zhou, Yi; Lynch, Gillian; Hogan, Josh; Leahy, Martin (AIP Publishing, 2019-09-16)Most of the fundamental pathological processes in living tissues exhibit changes at the nanoscale. Noninvasive, label-free detection of structural changes in biological samples pose a significant challenge to both researchers ...