Browsing College of Science by Title
Now showing items 36-55 of 970
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Analyzing protein conjugation reactions for antibody-drug conjugate synthesis using polarized excitation emission matrix spectroscopy
(Wiley, 2022-09-07)Antibody-drug conjugates (ADCs) are promising anticancer therapeutics, which offer important advantages compared to more classical therapies. There are a variety of ADC critical quality attributes (CQAs) such as the protein ... -
Analyzing time-course microarray data using functional data analysis - a review
(Statistical Applications in Genetics and Molecular Biology, 2011-05)Gene expression over time can be viewed as a continuous process and therefore represented as a continuous curve or function. Functional data analysis (FDA) is a statistical methodology used to analyze functional data ... -
Animal life history is shaped by the pace of life and the distribution of age-specific mortality and reproduction
(Nature Research (part of Springer Nature), 2019-07-08)Animals exhibit an extraordinary diversity of life history strategies. These realized combinations of survival, development and reproduction are predicted to be constrained by physiological limitations and by trade-offs ... -
Anisotropy resolved multidimensional emission spectroscopy (ARMES): A new tool for protein analysis
(Elsevier, 2015-07-30)Structural analysis of proteins using the emission of intrinsic fluorophores is complicated by spectral overlap. Anisotropy resolved multidimensional emission spectroscopy (ARMES) overcame the overlap problem by the use ... -
The annual GiG: Groups in Galway
(NUI Galway, 2015)The GiG (Groups in Galway) conference, and related activity, has been running annually since 1978 and is the longest running annual international mathematical conference on a special topic. It has its origin from the ... -
Anomer preferences for glucuronic and galacturonic acid and derivatives and influence of electron-withdrawing substituents
(American Chemical Society, 2018-07-04)Equilibrium anomeric ratios are reported for pyranoses (hemiacetals) of glucuronic and galacturonic acid and their derivatives. These are compared to related gluco- and galactopyranoses and to deoxyfluorogluco- and ... -
Antibacterial potential of an antimicrobial agent inspired by peroxidase-catalyzed systems
(Frontiers Media, 2017-05-02)Antibiotic resistance is an increasingly serious threat to global health. Consequently, the development of non-antibiotic based therapies and disinfectants, which avoid induction of resistance, or cross-resistance, is of ... -
Antitumor platinum(IV) derivatives of carboplatin and the histone deacetylase inhibitor 4-phenylbutyric acid
(Elsevier, 2017-09-10)Five new platinum(IV) derivatives of carboplatin each incorporating the histone deacetylase inhibitor 4-phenylbutyrate in axial position were synthesized and characterized by 1H and 195Pt NMR spectroscopy, electrospray ... -
Application of ball milling for highly selective mechanochemical polymorph transformations
(American Chemical Society, 2018-06-07)Milling is an important secondary processing technique in the manufacture of pharmaceuticals, primarily used as a particle size reduction process. p-Aminobenzoic acid (PABA), m-aminobenzoic acid (MABA), o-aminobenzoic acid ... -
Application of vibrational spectroscopy to study solid-state transformations of pharmaceuticals
(2016-09-01)Understanding the properties, stability and transformations of the solid-state forms of an active pharmaceutical ingredient (API) in the development pipeline is of crucial importance for process-development, formulation ... -
Applications of raman spectroscopy in biopharmaceutical manufacturing: A short review
(Sage Publications, 2017-05-23)The production of active pharmaceutical ingredients (APIs) is currently undergoing its biggest transformation in a century. The changes are based on the rapid and dramatic introduction of protein- and macromolecule-based ... -
Arsenic in groundwater in south west Ireland: Occurrence, controls, and hydrochemistry
(Frontiers Media, 2018-12-18)Globally numerous regions have been identified with elevated arsenic within groundwater which can result in potential adverse health risks. In Ireland, a previous national-scale research assessment of groundwater identified ... -
Assessing the predictions of a NOx kinetic mechanism on recent hydrogen and syngas experimental data
(Elsevier, 2017-05-02)A detailed chemical kinetic mechanism has been developed to describe the pyrolysis and oxidation of the hydrogen/NOx and syngas/NOx systems. The thermodynamic data of nitrogenous compounds have been updated based on the ... -
An assessment of RNA content in Prymnesium parvum, Prymnesium polylepis, cf. Chattonella sp. and Karlodinium veneficum under varying environmental conditions for calibrating an RNA microarray for species detection
(Wiley, 2014-02-03)Traditional methods of identification and enumeration can be somewhat ambiguous when identifying phytoplankton that requires electron microscopic examination to verify specific morphological features. Members of the genus ... -
Asteroid Day: a vehicle for raising public awareness of astronomy and space exploration among primary students in Ireland
(NUI Galway, 2018-03-24)Asteroid Day is a global awareness campaign which takes place annually to learn about asteroids, their impact and to increase awareness on how we can protect the Earth from future asteroid impacts. At the event students ... -
Asymptotic results for bifurcations in pure bending of rubber blocks
(Oxford Journals, 2008-03)The bifurcation of an incompressible neo-Hookean thick block with a ratio of thickness to length n, subject to pure bending, is considered. The two incremental equilibrium equations corresponding to a nonlinear pre-buckling ... -
At least three invariants are necessary to model the mechanical response of incompressible, transversely isotropic materials
(Springer, 2013-04-18)The modelling of off-axis simple tension experiments on transversely isotropic nonlinearly elastic materials is considered. A testing protocol is proposed where normal force is applied to one edge of a rectangular specimen ... -
Atomistic study of zwitterionic peptoid antifouling brushes
(NUI Galway, 2018-09-03)Simulation files, analysis scripts, and output data to accompany article: Cheung, David L., & Lau, King Hang Aaron. (2018). Atomistic Study of Zwitterionic Peptoid Antifouling Brushes. Langmuir. doi: 10.1021/acs.langm ... -
Atomistic study of zwitterionic peptoid antifouling brushes
(American Chemical Society, 2018-08-24)Using molecular dynamics (MD) simulations, we study the molecular behavior and hydration properties of a set of zwitterionic peptoid brushes, grafted on a rutile surface, that has been previously reported to exhibit ... -
ATPase activity of human binding immunoglobulin protein (BiP) variants is enhanced by signal sequence and physiological concentrations of Mn2+
(Wiley Open Access, 2019-08-29)B-cell immunoglobulin binding protein (BiP) is an essential endoplasmic reticulum (ER) chaperone normally found in the ER lumen. However, BiP also has other extracellular and intracellular functions. As it is unclear whether ...