Browsing School of Chemistry (Scholarly Articles) by Author "Herold-Mende, Christel"
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N-Alkyl-1,5-dideoxy-1,5-imino-l-fucitols as fucosidase inhibitors: Synthesis, molecular modelling and activity against cancer cell lines
Zhou, Jian; Negi, Arvind; Mirallai, Styliana I.; Warta, Rolf; Herold-Mende, Christel; Carty, Michael P.; Ye, Xin-Shan; Murphy, Paul V. (Elsevier, 2018-12-04)1,5-Dideoxy-1,5-imino-l-fucitol (1-deoxyfuconojirimycin, DFJ) is an iminosugar that inhibits fucosidases. Herein, N-alkyl DFJs have been synthesised and tested against the ¿-fucosidases of T. maritima (bacterial origin) ...