Browsing by Subject "Network of Excellence for Functional Biomaterials"
Now showing items 1-14 of 14
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A Biomaterials Approach for an Ex-Vivo Multiple Sclerosis Model of Inflammatory Demyelination
(2013-10-03)Multiple sclerosis (MS) is characterised by the presence of inflammatory demyelinating foci throughout the brain and spinal cord, accompanied by axonal and neuronal damage. Although inflammatory processes are thought to ... -
A biomaterials approach to peripheral nerve repair
(2014-04-09)Peripheral nerve injuries are a major clinical problem which currently affect over one million people worldwide. Transection injuries caused by workplace and home injuries, road traffic accidents and by intentional harm ... -
Controlling dispersion of axonal regeneration using a multichannel collagen nerve conduit
(Elsevier, 2010-03-21)Single channel conduits are used clinically in nerve repair as an alternative to the autologous nerve graft. Axons regenerating across single channel tubes, however, may disperse resulting in inappropriate target reinnervation. ... -
Design and development of polymeric transfection vectors for gene delivery in Recessive Dystrophic Epidermolysis Bullosa
(2014-07-23)Recessive Dystrophic Epidermolysis Bullosa (RDEB) is caused by mutations in the collagen VII gene (COL7A1) that lead to an alteration of function or a reduction in the amounts of collagen VII protein (C7). Any of these ... -
Developing reservoir systems for therapeutic delivery of biomolecules to a degenerated disc
(2015-01-05)Low back pain has severe consequences for the quality of life of the affected patients and strong evidence suggests that this condition is caused by degeneration of the intervertebral disc (IVD). Disc degeneration coincides ... -
Elastin-like polypeptide mediated proangiogenic and anti-inflammatory gene therapy for critical limb ischemia
(2014-12-17)Critical limb ischemia is a major clinical problem. Despite rigorous treatment regimes, there has been modest success in reducing the rate of amputations in these patients. Reduced level of blood flow and enhanced inflammation ... -
A Highly Effective Gene Delivery Vector
(The Royal Society of Chemistry, 2010-06)A hyperbranched 2-(dimethylamino)ethyl methacrylate (DMAEMA) based polymer has been synthesised by a one-pot in situ deactivation enhanced atom transfer radical polymerisation (DE-ATRP); it exhibits much higher transfection ... -
The influence of size and charge of chitosan/polyglutamic acid hollow spheres on cellular internalization, viability and blood compatibility
(Elsevier, 2010-11)Polymeric hollow spheres can be tailored as efficient carriers of various therapeutic molecules due to their tunable properties. However, the entry of these synthetic vehicles into cells, their cell viability and blood ... -
Liposomal gene delivery mediated by tissue-engineered scaffolds
(Elsevier, 2010-01-01)In the absence of any ideal gene delivery carrier despite the recent explosion of novel carrier systems, the current trend is to explore the complementary synergy promised by a combination of delivery systems such as ... -
Non-viral gene therapy for myocardial engineering
(John Wiley & Sons, Ltd., 2010-05)Despite significant advances in surgical and pharmacological techniques, myocardial infarction (MI) remains the main cause of morbidity in the developed world because no remedy has been found for the regeneration of infarcted ... -
A reliable method for detecting complexed DNA in vitro
(The Royal Society of Chemistry, 2010-09-08)Quantification of eluted nucleic acids is a critical parameter in characterizing biomaterial based gene-delivery systems. The most commonly used method is to assay samples with an intercalating fluorescent dye such as ... -
Spinal cord injury in vitro: Modelling axon growth inhibition
(Elsevier, 2010-06)Over the past three decades, tremendous progress has been made in elucidating mechanisms underlying regenerative failure after spinal cord injury and in devising therapeutic approaches to promote functional nerve regeneration. ... -
Strategies to Modify the Diatom Thalassiosira weissflogii for Use as a Biotemplate to Generate Hierarchical Polymeric Microcapsules
(2013-12-20)The aim of this research study was to generate a polymeric capsule with hierarchical architecture employing the diatom frustule as a sacrificial biotemplate. Both pennate and centric diatoms were isolated from Galway bay ... -
Type II collagen-hyaluronan hydrogel - a step towards a scaffold for intervertebral disc tissue engineering
(European Cells & Materials Ltd, 2010-09-06)Intervertebral disc regeneration strategies based on stem cell differentiation in combination with the design of functional scaffolds is an attractive approach towards repairing/regenerating the nucleus pulposus. The ...