Browsing by Subject "mice"
Now showing items 1-20 of 22
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A novel mouse model of in situ stenting
(Oxford University Press (OUP), 2009-07-25)Aims Animal models of stenting are mostly limited to larger animals or involve substantial abdominal surgery in rodents. We aimed to develop a simple, direct model of murine stenting. Methods and results We designed a ... -
Aerosol-mediated delivery of aav2/6-iκbα attenuates lipopolysaccharide-induced acute lung injury in rats
(Mary Ann Liebert Inc, 2015-01-01)Inhibition of the proinflammatory transcription factor NF-kappa B has previously been shown to attenuate the inflammatory response in tissue after injury. However, the feasibility and efficacy of aerosolized adeno-associated ... -
Allogeneic murine mesenchymal stem cells: migration to inflamed joints in vivo and amelioration of collagen induced arthritis when transduced to express ctla4ig
(Mary Ann Liebert Inc, 2013-12-15)Despite the immunosuppressive, homing, and regenerative capabilities of mesenchymal stem cells (MSCs), their ability to migrate to arthritic joints and influence the course of arthritis in vivo remains poorly understood. ... -
Altered neuropathic pain behaviour in a rat model of depression is associated with changes in inflammatory gene expression in the amygdala
(Wiley-Blackwell, 2013-08-01)The association between chronic pain and depression is widely recognized, the comorbidity of which leads to a heavier disease burden, increased disability and poor treatment response. This study examined nociceptive ... -
Altered thermoregulatory responses to clonidine in streptozotocin-diabetic rats
(Wiley-Blackwell, 1996-03-01)1 The effects of streptozotocin (STZ) treatment on alpha(2)-adrenoceptor regulation of body temperature were studied by monitoring the response of colonic temperature to administration of clonidine. 2 A dose-dependent fall ... -
Both human and mouse mesenchymal stem cells promote breast cancer metastasis
(Elsevier BV, 2011-09-01) -
Coaxing stem cells for skeletal muscle repair
(Elsevier BV, 2015-04-01) -
Combined oral toxicity of azaspiracid-1 and yessotoxin in female nmri mice
(Elsevier BV, 2011-05-01) -
Constitutive activation of ectodermal β-catenin induces ectopic outgrowths at various positions in mouse embryo and affects abdominal ventral body wall closure
(Public Library of Science (PLoS), 2014-03-19)Vertebrate limbs originate from the lateral plate mesoderm (LPM) and the overlying ectoderm. While normal limb formation in defined regions has been well studied, the question of whether other positions retain limb-forming ... -
Inflammation in aki: current understanding, key questions, and knowledge gaps
(American Society of Nephrology (ASN), 2015-11-11)Inflammation is a complex biologic response that is essential for eliminating microbial pathogens and repairing tissue after injury. AKI associates with intrarenal and systemic inflammation; thus, improved understanding ... -
Inhibition of pulmonary nuclear factor kappa-b decreases the severity of acute escherichia coli pneumonia but worsens prolonged pneumonia
(Springer Nature, 2013-01-01)Introduction: Nuclear factor (NF)-kappa B is central to the pathogenesis of inflammation in acute lung injury, but also to inflammation resolution and repair. We wished to determine whether overexpression of the NF-kappa ... -
Inhibitory effect of recombinant inos gene expression on vasomotor function of canine basilar artery
(American Physiological Society, 2002-08-22)The present study was designed to determine the effect of recombinant inducible nitric oxide (NO) synthase (iNOS) gene expression on vasomotor function in cerebral arteries. Isolated canine basilar arteries were exposed ... -
Insulin-like growth factor (igf) signalling is required for early dorso-anterior development of the zebrafish embryo
(UPV/EHU Press, 2004-01-01)The insulin-like growth factor (IGF) signalling pathway has been highly conserved in animal evolution and, in mammals and Xenopus, plays a key role in embryonic growth and development, with the IGF-1 receptor (IGF-1R) being ... -
Mesenchymal stem cell inhibition of t-helper 17 cell- differentiation is triggered by cell-cell contact and mediated by prostaglandin e2 via the ep4 receptor
(Wiley-Blackwell, 2011-08-30)Mesenchymal stem cells (MSCs) inhibit T-cell activation and proliferation but their effects on individual T-cell-effector pathways and on memory versus naive T cells remain unclear. MSC influence on the differentiation of ... -
Microneedle-mediated transdermal bacteriophage delivery
(Elsevier BV, 2012-09-01) -
Overexpression of wnt5a in mouse epidermis causes no psoriasis phenotype but an impairment of hair follicle anagen development
(Wiley-Blackwell, 2014-10-10)Increased Wnt5a expression has been observed in psoriatic plaques. However, whether Wnt5a overexpression directly causes psoriasis is unknown. In this study, we generated transgenic (TG) mice with epidermal Wnt5a overexpression ... -
Parp-1 protects homologous recombination from interference by ku and ligase iv in vertebrate cells
(Wiley-Blackwell, 2006-02-23)Parp-1 and Parp-2 are activated by DNA breaks and have been implicated in the repair of DNA single-strand breaks (SSB). Their involvement in double-strand break (DSB) repair mediated by homologous recombination (HR) or ... -
Solid phase extraction for removal of matrix effects in lipophilic marine toxin analysis by liquid chromatography-tandem mass spectrometry
(Springer Nature, 2009-04-24)The potential of solid phase extraction (SPE) clean-up has been assessed to reduce matrix effects (signal suppression or enhancement) in the liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis of lipophilic ... -
Structure elucidation, relative lc–ms response and in vitro toxicity of azaspiracids7–10isolated from mussels (mytilus edulis)
(American Chemical Society (ACS), 2015-05-27)Azaspiracids (AZAs) are marine biotoxins produced by dinoflagellates that can accumulate in shellfish, which if consumed can lead to poisoning events. AZA7-10, 7-10, were isolated from shellfish and their structures, ... -
Targeting the pim kinases in multiple myeloma
(Springer Nature, 2015-07-17)Multiple myeloma (MM) is a plasma cell malignancy that remains incurable. Novel treatment strategies to improve survival are urgently required. The Pims are a small family of serine/threonine kinases with increased expression ...