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    Overexpression of wnt5a in mouse epidermis causes no psoriasis phenotype but an impairment of hair follicle anagen development

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    Date
    2014-10-10
    Author
    Zhu, Xuming
    Wu, Yumei
    Huang, Sixia
    Chen, Yingwei
    Tao, Yixin
    Wang, Yushu
    He, Shigang
    Shen, Sanbing
    Wu, Ji
    Guo, Xizhi
    Li, Baojie
    He, Lin
    Ma, Gang
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    Recommended Citation
    Zhu, Xuming; Wu, Yumei; Huang, Sixia; Chen, Yingwei; Tao, Yixin; Wang, Yushu; He, Shigang; Shen, Sanbing; Wu, Ji; Guo, Xizhi; Li, Baojie; He, Lin; Ma, Gang (2014). Overexpression of wnt5a in mouse epidermis causes no psoriasis phenotype but an impairment of hair follicle anagen development. Experimental Dermatology 23 (12), 926-928
    Published Version
    http://onlinelibrary.wiley.com/doi/10.1111/exd.12539/pdf
    Abstract
    Increased Wnt5a expression has been observed in psoriatic plaques. However, whether Wnt5a overexpression directly causes psoriasis is unknown. In this study, we generated transgenic (TG) mice with epidermal Wnt5a overexpression under the control of the human K14 promoter. The skin of Wnt5a TG mice was not psoriatic, but characterized with normal proliferation and homeostasis of epidermis. Instead, these TG mice displayed impaired hair follicle transition from telogen to anagen, most likely due to impaired canonical Wnt signalling. These results suggest that increased Wnt5a expression alone is inadequate to induce psoriasis in the skin and possible involvement of Wnt5a in hair follicle cycling.
    URI
    http://hdl.handle.net/10379/14538
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