Browsing by Subject "central-nervous-system"
Now showing items 1-13 of 13
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An evolutionarily conserved soxb-hdac2 crosstalk regulates neurogenesis in a cnidarian
(Elsevier BV, 2017-02-01)SoxB transcription factors and histone deacetylases (HDACs) are each major players in the regulation of neurogenesis, but a functional link between them has not been previously demonstrated. Here, we show that SoxB2 and ... -
Changes in the immune system in rodent models of depression
(Oxford University Press (OUP), 2002-12-01)This review summarizes some of the evidence which implicates an increase in the peripheral and central secretion of pro-inflammatory cytokines in the behavioural changes seen in some stress-induced and brain lesion models ... -
Gdnf gene delivery via a 2-(dimethylamino)ethyl methacrylate based cyclized knot polymer for neuronal cell applications
(American Chemical Society (ACS), 2013-04-17)Nonviral genetic therapeutic intervention strategies for neurological disorders hold great promise, but a lack of vector efficacy, coupled with vector toxicity, continue to hinder progress. Here we report the application ... -
Intracellular mechanisms underlying the nicotinic enhancement of ltp in the rat dentate gyrus
(Wiley-Blackwell, 2009-01-01)We have previously shown that activation of nicotinic acetylcholine receptors (nAChRs) enhanced long-term potentiation (LTP) in the rat dentate gyrus in vitro via activation of alpha 7 nAChR. In the present studies, ... -
Progressive fatal myelopathy secondary to isolated spinal cord vasculitis
(Frontiers Media SA, 2017-12-19)A 56-year-old woman with various neurological signs which developed over a 1-year period was admitted for evaluation. MRI showed a markedly abnormal signal in the cervical spine. Despite treatment with IV steroids, she ... -
Recent advances in psychoneuroimmunology: inflammation in psychiatric disorders
(Walter de Gruyter GmbH, 2011-01-01)Psychiatric disorders are common and complex and their precise biological underpinnings remain elusive. Multiple epidemiological, molecular, genetic and gene expression studies suggest that immune system dysfunction may ... -
Sterile post-traumatic immunosuppression
(Springer Nature, 2016-04-29)After major trauma, the human immune system initiates a series of inflammatory events at the injury site that is later followed by suppression of local inflammation favoring the repair and remodeling of the damaged tissues. ... -
The evolutionary history of vertebrate cranial placodes ii. evolution of ectodermal patterning
(Elsevier BV, 2014-05-01) -
The evolutionary history of vertebrate cranial placodes – i: cell type evolution
(Elsevier BV, 2014-05-01) -
The structural and functional role of myelin fast-migrating cerebrosides: pathological importance in multiple sclerosis
(Future Medicine Ltd, 2011-04-01)A family of neutral glycosphingolipids containing a 3-O-acetyl-sphingosine galactosylceramide (3-SAG) has been characterized. Seven new derivatives of galactosylceramide (GalCer), designated as fast-migrating cerebrosides ... -
Toward customized extracellular niche engineering: progress in cell-entrapment technologies
(Wiley-Blackwell, 2017-12-01)The primary aim in tissue engineering is to repair, replace, and regenerate dysfunctional tissues to restore homeostasis. Cell delivery for repair and regeneration is gaining impetus with our understanding of constructing ... -
ulk4 deficiency leads to hypomyelination in mice
(Wiley-Blackwell, 2017-10-16)Brain nerve fibers are insulated by myelin which is produced by oligodendrocytes. Defects in myelination are increasingly recognized as a common pathology underlying neuropsychiatric and neurodevelopmental disorders, which ...