Search
Now showing items 1-10 of 10
Fluorescent labeling of nasba amplified tmrna molecules for microarray applications
(Springer Nature, 2009-01-01)
Background: Here we present a novel promising microbial diagnostic method that combines the sensitivity of Nucleic Acid Sequence Based Amplification (NASBA) with the high information content of microarray technology for ...
Bcl-2 polymorphism influences gray matter volume in the ventral striatum in healthy humans
(Elsevier BV, 2009-10-01)
Background: Bcl-2 is a major regulator of neural plasticity and cellular resilience. A single nucleotide polymorphism (SNP) in the Bcl-2 gene, Bcl-2 rs956572, significantly modulates the expression of Bcl-2 protein and ...
Phenylenediamine-based bivalent glycocyclophanes: synthesis and analysis of the influence of scaffold rigidity and ligand spacing on lectin binding in cell systems with different glycomic profiles
(Royal Society of Chemistry (RSC), 2009-01-01)
The conjugation of carbohydrates to synthetic scaffolds has the goal of preparing potent inhibitors of lectin binding. We herein report the synthesis of a panel of bivalent compounds (cyclophane and terephthalamide-derivatives) ...
Cutting edge: il-7 regulates the peripheral pool of adult ror + lymphoid tissue inducer cells
(The American Association of Immunologists, 2009-07-27)
During fetal life, CD4(+)CD3(-) lymphoid tissue inducer (LTi) cells are required for lymph node and Peyer's patch development in mice. In adult animals, CD4(+) CD3(-) cells are found in low numbers in lymphoid organs. ...
Reduced occipital and prefrontal brain volumes in dysbindin-associated schizophrenia
(Springer Nature, 2009-09-30)
A three-marker C-A-T dysbindin haplotype identified by Williams et al (PMID: 15066891) is associated with increased risk for schizophrenia, decreased mRNA expression, poorer cognitive performance, and early sensory processing ...
Enhanced antitumor efficacy of a dr5-specific trail variant over recombinant human trail in a bioluminescent ovarian cancer xenograft model
(American Association for Cancer Research (AACR), 2009-03-10)
Purpose: Recombinant human tumor necrosis factor-related apoptosis-inducing ligand (rhTRAIL) is clinically evaluated as novel anticancer drug. rhTRAIL-DR5, a rhTRAIL variant that specifically binds to DR5 receptor, has ...
Microrna signatures predict oestrogen receptor, progesterone receptor and her2/neureceptor status in breast cancer
(Springer Nature, 2009-05-11)
Introduction Breast cancer is a heterogeneous disease encompassing a number of phenotypically diverse tumours. Expression levels of the oestrogen, progesterone and HER2/neu receptors which characterize clinically distinct ...
Bioconductorbuntu: a linux distribution that implements a web-based dna microarray analysis server
(Oxford University Press (OUP), 2009-03-23)
BioconductorBuntu is a custom distribution of Ubuntu Linux that automatically installs a server-side microarray processing environment, providing a user-friendly web-based GUI to many of the tools developed by the Bioconductor ...
Proinflammatory action of the antiinflammatory drug infliximab in tumor necrosis factor receptor-associated periodic syndrome
(Wiley-Blackwell, 2009-02-01)
Objective. Tumor necrosis factor receptor (TNFR) -associated periodic syndrome (TRAPS) is an autosomal-dominant autoinflammatory condition caused by mutations in the TNFRSFIA gene. Unlike other autoinflammatory diseases ...