Cutting edge: il-7 regulates the peripheral pool of adult ror + lymphoid tissue inducer cells
Rolink, A. G.
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Schmutz, S. Bosco, N.; Chappaz, S.; Boyman, O.; Acha-Orbea, H.; Ceredig, R.; Rolink, A. G.; Finke, D. (2009). Cutting edge: il-7 regulates the peripheral pool of adult ror + lymphoid tissue inducer cells. The Journal of Immunology 183 (4), 2217-2221
During fetal life, CD4(+)CD3(-) lymphoid tissue inducer (LTi) cells are required for lymph node and Peyer's patch development in mice. In adult animals, CD4(+) CD3(-) cells are found in low numbers in lymphoid organs. Whether adult CD4(+)CD3(-) cells are LTi cells and are generated and maintained through cytokine signals has not been directly addressed. In this study we show that adult CD4(+)CD3(-) cells adoptively transferred into neonatal CXCR5(-/-) mice induced the formation of intestinal lymphoid tissues, demonstrating for the first time their bona fide LTi function. Increasing IL-7 availability in wild-type mice either by IL-7 transgene expression or treatment with IL-7/anti-IL-7 complexes increased adult LTi cell numbers through de novo generation from bone marrow cells and increased the survival and proliferation of LTi cells. Our observations demonstrate that adult CD4(+)lineage(-) cells are LTi cells and that the availability of IL-7 determines the size of the adult LTi cell pool. The Journal of Immunology, 2009,183:2217-2221.