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Vspipe, an integrated resource for virtual screening and hit selection: applications to protein tyrosine phospahatase inhibition
(MDPI AG, 2018-02-07)
The use of computational tools for virtual screening provides a cost-efficient approach to select starting points for drug development. We have developed VSpipe, a user-friendly semi-automated pipeline for structure-based ...
Analysis of shared heritability in common disorders of the brain
(American Association for the Advancement of Science (AAAS), 2018-06-21)
Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide ...
Iodine content in bulk biomass of wild-harvested and cultivated edible seaweeds: inherent variations determine species-specific daily allowable consumption
(Elsevier BV, 2018-02-01)
This study represents a large-scale investigation into iodine contents in three commercially important and edible seaweed species from the North Atlantic: the brown algae Saccharina latissima and Alaria esculenta, and the ...
Prevalence of bovine viral diarrhoea virus (bvdv), bovine herpes virus 1 (bhv 1), leptospirosis and neosporosis, and associated risk factors in 161 irish beef herds
(Springer Nature, 2018-01-06)
Background: There are limited data available, in Ireland or elsewhere, to determine the extent of exposure to various endemic diseases among beef cows and factors associated with exposure to causative pathogens. The ...
Duragraft vascular conduit preservation solution in patients undergoing coronary artery bypass grafting: rationale and design of a within-patient randomised multicentre trial
(BMJ, 2018-04-01)
Introduction Saphenous vein grafts (SVGs) remain the most often used conduits in coronary artery bypass grafting (CABG). However, they are prone to vein graft disease (VGD) during follow-up, which may compromise clinical ...
Clinical experience with regenerative therapy in heart failure
(Ovid Technologies (Wolters Kluwer Health), 2018-05-10)
Adoption of regenerative strategies for heart failure is challenged by mixed outcomes in clinical trials. Ongoing development plans strive to improve biotherapeutic potency, optimize delivery, standardize dosing, and target ...
Disease mentions in airport and hospital geolocations expose dominance of news events for disease concerns
(Springer Nature, 2018-06-12)
Background: In recent years, Twitter has been applied to monitor diseases through its facility to monitor users' comments and concerns in real-time. The analysis of tweets for disease mentions should reflect not only user ...
Lyapunov functions to caputo fractional neural networks with time-varying delays
(MDPI AG, 2018-05-09)
One of the main properties of solutions of nonlinear Caputo fractional neural networks is stability and often the direct Lyapunov method is used to study stability properties (usually these Lyapunov functions do not depend ...
Using eddy covariance to measure the dependence of air–sea co<sub>2</sub> exchange rate on friction velocity
(Copernicus GmbH, 2018-03-28)
Parameterisation of the air-sea gas transfer velocity of CO2 and other trace gases under open-ocean conditions has been a focus of air-sea interaction research and is required for accurately determining ocean carbon uptake. ...
Cost-effectiveness of healthy eating and/or physical activity promotion in pregnant women at increased risk of gestational diabetes mellitus: economic evaluation alongside the dali study, a european multicenter randomized controlled trial
(Springer Nature, 2018-03-14)
Background: Gestational diabetes mellitus (GDM) is associated with perinatal health risks to both mother and offspring, and represents a large economic burden. The DALI study is a multicenter randomized controlled trial, ...