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A 3′-untranslated region kras variant and triple-negative breast cancer: a case-control and genetic analysis
(Elsevier BV, 2011-04-01)
Background We previously identified a functional variant in a let-7 microRNA (miRNA) complementary site in the 3'-untranslated region of the KRAS oncogene (rs61764370) which is associated with cancer. We aimed to investigate ...
Subdomains n2n3 of fibronectin binding protein a mediate staphylococcus aureus biofilm formation and adherence to fibrinogen using distinct mechanisms
(American Society for Microbiology, 2013-04-05)
Health care-associated methicillin-resistant Staphylococcus aureus (HA-MRSA) forms biofilm in vitro that is dependent on the surface-located fibronectin binding proteins A and B (FnBPA, FnBPB). Here we provide new insights ...
Disaggregating polyploidy, parental genome dosage and hybridity contributions to heterosis in arabidopsis thaliana
(Wiley-Blackwell, 2015-09-23)
Heterosis is the phenomenon whereby hybrid offspring of genetically divergent parents display superior characteristics compared with their parents. Although hybridity and polyploidy can influence heterosis in hybrid plants, ...
Elacytarabine has single-agent activity in patients with advanced acute myeloid leukaemia
(Wiley-Blackwell, 2012-06-15)
Elacytarabine is a novel cytotoxic nucleoside analogue, independent of nucleoside transporters (e.g. human Equilibrative Nucleoside Transporter 1 [hENT1]) for cell uptake, and mechanisms of action similar to those of ...
Role of lentivirus-mediated overexpression of programmed death-ligand 1 on corneal allograft survival
(Wiley-Blackwell, 2012-02-02)
To investigate the role of lentivirus-mediated overexpression of programmed death-ligand 1 (PD-L1) on rat corneal allograft survival. A fully allogeneic rat cornea transplant model was used for in vivo studies. Lentiviral ...
The role of c1q in recognition of apoptotic epithelial cells and inflammatory cytokine production by phagocytes during helicobacter pylori infection
(Springer Nature, 2015-09-08)
Background: Gastric epithelial cells (GECs) undergo apoptosis during H. pylori infection and phagocytes within the mucosa engulf these cells. The recognition and clearance of apoptotic cells is a multifactorial process, ...
The cell cycle regulator phosphorylated retinoblastoma protein is associated with tau pathology in several tauopathies
(Oxford University Press (OUP), 2011-07-01)
Retinoblastoma protein (pRb) is a ubiquitous 928-amino acid cell cycle regulatory molecule with diverse biologic activities. One critical function of pRb is the control of the G(1)-to-S phase checkpoint of the cell cycle. ...
Fasciola hepaticasurface tegument: glycoproteins at the interface of parasite and host
(American Society for Biochemistry & Molecular Biology (ASBMB), 2016-07-27)
Fasciola hepatica, commonly known as liver fluke, is a trematode that causes Fasciolosis in ruminants and humans. The outer tegumental coat of F. hepatica (FhTeg) is a complex metabolically active biological matrix that ...
Presence of terminal n-acetylgalactosamineβ1-4n-acetylglucosamine residues on o-linked oligosaccharides from gastric muc5ac: involvement in helicobacter pylori colonization?
(Oxford University Press (OUP), 2012-04-26)
Isolation of MUC5AC mucins from the gastric mucosa from two secretor individuals (one from normal mucosa from a patient with gastric cancer and one from a control) showed different abilities to bind and induce the proliferation ...
Newly identified genetic risk variants for celiac disease related to the immune response
(Springer Nature, 2008-03-02)
Our genome-wide association study of celiac disease previously identified risk variants in the IL2-IL21 region. To identify additional risk variants, we genotyped 1,020 of the most strongly associated non-HLA markers in ...