Browsing National Centre for Biomedical Engineering Science (Scholarly Articles) by Issue Date
Now showing items 41-60 of 79
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Ghrelin in the human myometrium
(2010)Background: Ghrelin is a 28-amino acid octanolyated peptide, synthesised primarily in the stomach. It stimulates growth hormone release, food intake and exhibits many other diverse effects. Our group have previously ... -
Recent advances in the development of nucleic acid diagnostics
(2010)Since the early 1970s, the use of nucleic acid sequences for specific diagnostic applications has followed a somewhat linear pattern of development. Early methods for restriction enzyme digestion, as well as reverse ... -
Testes and brain gene expression in precocious male and adult maturing Atlantic salmon (Salmo salar)
(BioMed Central, 2010)Background: The male Atlantic salmon generally matures in fresh water upon returning after one or several years at sea. Some fast-growing male parr develop an alternative life strategy where they sexually mature before ... -
Microscale flow structures measured downstream of a mechanical heart valve
(Trinity College Dublin, 2010-01-22) -
Use of microarray technology to assess the time course of liver stress response after confinement exposure in gilthead sea bream (Sparus aurata L.)
(BioMed Central, 2010-03-22)Background: Selection programs for growth and stress traits in cultured fish are fundamental to the improvement of aquaculture production. The gilthead sea bream ( Sparus aurata) is the main aquacultured species in the ... -
Incompressible moving boundary flows with the finite volume particle method
(Elsevier, 2010-03-24)Mesh-free methods offer the potential for greatly simplified modeling of flow with moving walls and phase interfaces. The finite volume particle method (FVPM) is a mesh-free technique based on interparticle fluxes which ... -
Ghrelin in the human myometrium
(BioMed Central Ltd, 2010-03-29)Ghrelin is a 28-amino acid octanolyated peptide, synthesised primarily in the stomach. It stimulates growth hormone release, food intake and exhibits many other diverse effects. Our group have previously determined that ... -
Mesenchymal stem cells and osteoarthritis: remedy or accomplice?
(Mary Ann Liebert, Inc., 2010-10)Multipotent mesenchymal stromal or stem cells (MSCs) are likely to be agents of connective tissue homeostasis and repair. Because the hallmark of osteoarthritis (OA) is degeneration and failure to repair connective tissues ... -
Allele-specific transcriptional elongation regulates monoallelic expression of the IGF2BP1 gene
(2011)Background Random monoallelic expression contributes to phenotypic variation of cells and organisms. However, the epigenetic mechanisms by which individual alleles are randomly selected for expression are not known. ... -
Acquired Activated Protein C Resistance, Thrombophilia and Adverse Pregnancy Outcomes: A Study Performed in an Irish Cohort of Pregnant Women
(2011)The combination of thrombophilia and pregnancy increases the risk of thrombosis and the potential for adverse outcomes during pregnancy. The most significant common inherited risk factor for thrombophilia is activated ... -
Anterior cruciate ligament graft tensioning. Is the maximal sustained one-handed pull technique reproducible?
(2011)Background Tensioning of anterior cruciate ligament (ACL) reconstruction grafts affects the clinical outcome of the procedure. As yet, no consensus has been reached regarding the optimum initial tension in an ACL graft. ... -
DNA mediated chromatin pull-down for the study of chromatin replication
(2011)Chromatin replication involves duplicating DNA while maintaining epigenetic information. These processes are critical for genome stability and for preserving cell-type identity. Here we describe a simple experimental ... -
Periodic acid-Schiff's reagent assay for carbohydrates in a microtiter plate format
(2011)Microtiter plate colorimetric assays are widely used for analysis of carbohydrates and glycoconjugates. However, mucins are often not easily detected, as they have low neutral sugar content. We have adapted and optimised ... -
Regulation of the DNA Damage Response and Gene Expression by the Dot1L Histone Methyltransferase and the 53Bp1 Tumour Suppressor
(PLoS, 2011-02)Background Dot1L, a histone methyltransferase that targets histone H3 lysine 79 (H3K79), has been implicated in gene regulation and the DNA damage response although its functions in these processes remain poorly ... -
Kinase Inhibitor against Quiescent and Proliferating CLL Cells
(2011-07-18)In chronic lymphocytic leukemia (CLL) the proliferation rate and resistance to drug-induced apoptosis are recognized as important factors in the outcome of treatment. In this study, we assess the activity and the mechanism ... -
Analysis of stress-induced hepatic gene expression in rainbow trout (Oncorhynchus mykiss) selected for high- and low-responsiveness to stress
(Elsevier, 2011-12)The production and welfare of intensively reared fish would be improved by reducing stress responsiveness. One approach to achieving this goal is selective breeding utilising stress-responsive genes as direct genetic markers ... -
Dietary vegetable oils do not alter the intestine transcriptome of gilthead sea bream (Sparus aurata), but modulate the transcriptomic response to infection with Enteromyxum leei
(BioMed Central, 2012)Background: Studies conducted with gilthead sea bream (Sparus aurata L.) have determined the maximum dietary replacement of fish meal and oil without compromising growth or product quality. The present study aimed to analyze ... -
Laser sintering for the fabrication of tissue engineering scaffolds
(Springer Science+Business Media, 2012)Laser sintering (LS) utilises a laser to sinter powder particles. A volumetric model is sliced and processedcross section by cross section to create a physical part. In theory, all powdered materials are suitable forsintering; ... -
Interaction of cell culture with composition effects on the mechanical properties of polycaprolactone-hydroxyapatite scaffolds fabricated via selective laser sintering (SLS)
(Elsevier, 2012)In the current study PCL/HA composites were fabricated using SLS as two- and three-dimensional lattice structures and exposed to a cellular component (MC 313 osteoblast-like cells). The main aims were to determine the ...