Browsing School of Medicine by Title
Now showing items 93-112 of 212
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Home detection of freezing of gait using support vector machines through a single waist-worn triaxial accelerometer
(Public Library of Science, 2017-02-15)Among Parkinson's disease (PD) symptoms, freezing of gait (FoG) is one of the most debilitating. To assess FoG, current clinical practice mostly employs repeated evaluations over weeks and months based on questionnaires, ... -
Hypoxia activates the PTHrP-MEF2C pathway to attenuate hypertrophy in mesenchymal stem cell derived cartilage
(Nature Research, 2019-09-16)Articular cartilage lacks an intrinsic repair capacity and due to the ability of mesenchymal stem cells (MSCs) to differentiate into chondrocytes, MSCs have been touted as a cellular source to regenerate damaged cartilage. ... -
Identifying and addressing the limitations of safety climate surveys.
(Elsevier, 2011-06)This paper reports the descriptive analysis of a large sample of safety climate survey data (n = 110,014) collected over 10 years from U.S. Naval aircrew using the Command Safety Assessment Survey (CSAS). -
Impact of diabetes mellitus on bone health
(MDPI, 2019-09-30)Long-term exposure to a diabetic environment leads to changes in bone metabolism and impaired bone micro-architecture through a variety of mechanisms on molecular and structural levels. These changes predispose the bone ... -
Impact of mesenchymal stem cell secreted PAI-1 on colon cancer cell migration and proliferation
(Elsevier, 2013-05-16)Mesenchymal Stem Cells are known to engraft and integrate into the architecture of colorectal tumours, with little known regarding their fate following engraftment. This study aimed to investigate mediators of Mesenchymal ... -
Impact of working 48 hours per week on opportunities for training and patient contact: the experience of Irish interns
(Oxford University Press, 2015-09-29)Objective. The European Working Time Regulations (EWTR) have been criticised for its purported negative impact on the training of junior doctors. The aim of this study was to examine the amount of time interns spent ... -
Impaired cued and spatial learning performance and altered cannabinoid CB1 receptor functionality in the substantia nigra in a rat model of diabetic neuropathy
(Elsevier, 2016-01-13)Diabetes, and associated diabetic neuropathic pain, impact negatively on cognitive function. However, the underlying mechanisms remain poorly understood. This study investigated neuropathic pain-related behaviour and ... -
Impaired recognition memory and cognitive flexibility in the rat L5-L6 spinal nerve ligation model of neuropathic pain
(De Gruyter, 2016-01-01)Background and aims: Although neuropathic pain is known to negatively affect cognition, the neural mechanisms involved are poorly understood. Chronic pain is associated with changes in synaptic plasticity in the brain which ... -
Improving antimicrobial prescribing: a multinomial model identifying factors associated with first- and second-line prescribing
(Elsevier, 2018-12-13)Background/objectives: Broad-spectrum, second-line antimicrobials may be prescribed when initial first-line options prove ineffective. This study compares prescribing practices and identifies potential influencing factors ... -
In memory of Tom Isaacs: The epitomical mover and shaker
(Wiley, 2018-10-16)[No abstract available] -
Incidental findings on MRI scans of patients presenting with audiovestibular symptoms
(Biomed Central, 2010)Background:The evaluation of patients presenting with audiovestibular symptoms usually includes MRI of the internal auditory meatus, the cerebellopontine angle and the brain. A significant percentage of these scans will ... -
Indistinguishable NDM-producing escherichia coli isolated from recreational waters, sewage, and a clinical specimen in Ireland, 2016 to 2017
(European Centre for Disease Prevention and Control, 2017-04-13)In this study, New Delhi metallo-beta-lactamase (NDM)-producing Enterobacteriaceae were identified in Irish recreational waters and sewage. Indistinguishable NDM-producing Escherichia coli by pulsed-field gel electrophoresis ... -
Inertial sensor technology for elite swimming performance analysis: a systematic review
(MDPI, 2015-12-25)Technical evaluation of swimming performance is an essential factor of elite athletic preparation. Novel methods of analysis, incorporating body worn inertial sensors (i.e., Microelectromechanical systems, or MEMS, ... -
Influence of stromal–epithelial interactions on breast cancer in vitro and in vivo
(Springer, 2011-02-23)Stromal cell-secreted chemokines including CCL2 have been implicated in the primary tumor microenvironment, as mediators of tumor cell migration, proliferation, and angiogenesis. Expression of CCL2 and its principal receptor ... -
Inhibition by Anandamide of 6-Hydroxydopamine-Induced Cell Death in PC12 Cells
(2010)6-hydroxydopamine (6-OHDA) is a selective neurotoxin that is widely used to investigate cell death and protective strategies in models of Parkinson's disease. Here, we investigated the effects of the endogenous cannabinoid, ... -
Interns and their smartphones: use for clinical practice
(Medscape, 2014)Purpose of the study Smartphone use among healthcare professionals has become widespread and will continue to grow in the coming years.Study design In October 2012, a survey was distributed to 230 interns at two of the ... -
Intervention to improve the quality of antimicrobial prescribing for urinary tract infection: a cluster randomized trial
(Canadian Medical Association, 2015-11-16)Background: Overuse of antimicrobial therapy in the community adds to the global spread of antimicrobial resistance, which is jeopardizing the treatment of common infections.Methods: We designed a cluster randomized complex ... -
Investigating the management of diabetes in nursing homes using a mixed methods approach
(Elsevier ScienceDirect, 2017-03-21)Aims: As populations age there is an increased demand for nursing home (NH) care and a parallel increase in the prevalence of diabetes. Despite this, there is growing evidence that the management of diabetes in NHs is ... -
Involvement of the endocannabinoid system in attentional modulation of nociceptive behaviour in rats
(Wiley, 2014-11-15)BackgroundDistraction is used clinically to relieve and manage pain. It is hypothesized that pain demands attention and that exposure to another attention-demanding stimulus causes withdrawal of attention away from painful ... -
The Irish DAFNE Study Protocol: A cluster randomised trial of group versus individual follow-up after structured education for Type 1 diabetes
(2009)Background: Structured education programmes for individuals with Type 1 diabetes have become a recognised means of delivering the knowledge and skills necessary for optimal self-management of the condition. The Dose ...