Browsing School of Medicine by Title
Now showing items 19-38 of 336
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Anandamide modulation of endotoxin-induced inflammation
(OMICS International, 2013-12-20)The endocannabinoid system is comprised of the CB1 and CB2 receptors, the naturally occurring endogenous ligands, anandamide (AEA) and 2-arachidonyl glycerol (2-AG); and the enzymes involved in their synthesis and ... -
Animal models of focal cerebral ischaemia and haemorrhage transformation: considerations in experimental stroke study design
(Bentham Science Publishers, 2017)Background: Ischaemic stroke is often complicated with haemorrhage within the infarct zone or in a remote location especially when treated with intravenous thrombolysis and/or thrombectomy. While these early recanalisation ... -
Anti-donor immune responses elicited by allogeneic mesenchymal stem cells and their extracellular vesicles: Are we still learning?
(Frontiers Media, 2017-11-24)Mesenchymal stromal cells (MSC) have been used to treat a broad range of disease indications such as acute and chronic inflammatory disorders, autoimmune diseases, and transplant rejection due to their potent immunosuppr ... -
Antimicrobial management and appropriateness of treatment of urinary tract infection in general practice in Ireland
(2011)ABSTRACT: BACKGROUND: Urinary tract infections (UTIs) are the second most common bacterial infections in general practice and a frequent indication for prescription of antimicrobials. Increasing concern about the association ... -
Antinociceptive effects of the GPR55 Antagonist CID16020046 injected into the rat anterior cingulate cortex
(Elsevier, 2020-07-13)The G-protein coupled receptor, GPR55, modulates nociceptive processing. Given the expression of GPR55 in the anterior cingulate cortex (ACC), a key brain region involved in the cognitive and affective dimensions of pain, ... -
The application of human reliability analysis to three critical care procedures
(Elsevier, 2020-07-10)Background: Procedures carried out in the intensive care unit are prone to human error. Standardisation has been suggested as an approach for reducing errors. This study used human reliability analysis methodologies to ... -
Application of video-based methods for competitive swimming analysis: a systematic review
(2015)This paper explores the application of video-based methods for the analysis of com- petitive swimming performance. A systematic search of the existing literature was conducted using the following keywords: swim*, performance, ... -
Artificial cornea: Past, current, and future directions
(Frontiers Media, 2021-11-12)Corneal diseases are a leading cause of blindness with an estimated 10 million patients diagnosed with bilateral corneal blindness worldwide. Corneal transplantation is highly successful in low-risk patients with corneal ... -
ASPiH Conference 2019 keynote paper. Quality improvement through simulation: a missed opportunity?
(BMJ Publishing Group, 2020-03-04)As the use of simulation has become more established in the delivery of healthcare education and training, there has been a corresponding increase in healthcare simulation research. Simulation-based research can be divided ... -
Assembly of protein-based hollow spheres encapsulating a therapeutic factor
(American Chemical Society, 2013-06-13)Neurotrophins, as important regulators of neural development, function and survival, have a therapeutic potential to repair damaged neurons. However, a controlled delivery of therapeutic molecules to injured tissue remains ... -
The association of white matter volume in psychotic disorders with genotypic variation in NRG1, MOG and CNP: a voxel-based analysis in affected individuals and their unaffected relatives
(Nature Publishing Group, 2012)We investigated the role of variation in putative psychosis genes coding for elements of the white matter system by examining the contribution of genotypic variation in three single-nucleotide polymorphisms (SNPs) neuregulin ... -
Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies
(Elsevier, 2016-05-20)Background Several studies reported a U-shaped association between urinary sodium excretion and cardiovascular disease events and mortality. Whether these associations vary between those individuals with and without ... -
ATLANTIC DIP: pregnancy outcome for women with pregestational diabetes along the Irish Atlantic seaboard.
(2009)OBJECTIVE Prospective evaluation of pregnancy outcomes in pregestational diabetes along the Atlantic seaboard 2006¿2007. RESEARCH DESIGN AND METHODS The Atlantic Diabetes in Pregnancy group, representing five antenatal ... -
ATLANTIC DIP: simplifying the follow-up of women with previous gestational diabetes
(European Society of Endocrinology, 2013)Objective: Previous gestational diabetes (GDM) is associated with a significant lifetime risk of type 2 diabetes. In this study, we assessed the performance of HbA1c and fasting plasma glucose (FPG) measurements against ... -
ATLANTIC-DIP- Prevalence of metabolic syndrome and insulin resistance in women with previous gestational diabetes mellitus by International Association of Diabetes in Pregnancy Study Groups criteria
(Springer, 2014-07-08)Women with previous gestational diabetes (GDM) are a high-risk group for future development of diabetes, metabolic syndrome, and cardiovascular disease. The new International Association of Diabetes in Pregnancy Study ... -
Attenuation of fear‐conditioned analgesia in rats by monoacylglycerol lipase inhibition in the anterior cingulate cortex: Potential role for CB2 receptors
(The British Pharmacological Society, 2020-01-22)Improved understanding of brain mechanisms regulating endogenous analgesia is important from a fundamental physiological perspective and for identification of novel therapeutic strategies for pain. The endocannabinoid ... -
Barriers and facilitators related to the implementation of a physiological track and trigger system: A systematic review of the qualitative evidence
(Oxford University Press (OUP), 2017-11-21)Purpose To identify the barriers to, and facilitators of, the implementation of physiological track and trigger systems (PTTSs), perceived by healthcare workers, through a systematic review of the extant qualitative ... -
Behaviour change techniques targeting both diet and physical activity in type 2 diabetes: A systematic review and meta-analysis
(BioMed Central, 2017-02-08)Background: Changing diet and physical activity behaviour is one of the cornerstones of type 2 diabetes treatment, but changing behaviour is challenging. The objective of this study was to identify behaviour change techniques ... -
Behavioural, neurochemical and neuroendocrine effects of the endogenous beta-carboline harmane in fear-conditioned rats
(2012)The putative endogenous imidazoline binding site ligand harmane enhances neuronal activation in response to psychological stress and alters behaviour in animal models of anxiety and antidepressant efficacy. However, the ... -
Bipolar disorder and gender are associated with frontolimbic and basal ganglia dysconnectivity: A study of topological variance using network analysis
(Mary Ann Liebert, 2019-12-16)Well-established structural abnormalities, mostly involving the limbic system, have been associated with disorders of emotion regulation. Understanding the arrangement and connections of these regions with other functionally ...