Browsing Medicine by Author "http://dx.doi.org/10.13039/501100007601"

Now showing items 1-8 of 8

    • Artificial cornea: Past, current, and future directions 

      Holland, Gráinne; Pandit, Abhay; Sánchez-Abella, Laura; Haiek, Andrea; Loinaz, Iraida; Dupin, Damien; Gonzalez, Maria; Larra, Eva; Bidaguren, Aritz; Lagali, Neil; Moloney, Elizabeth B.; Ritter, Thomas (Frontiers Media, 2021-11-12)
      Corneal diseases are a leading cause of blindness with an estimated 10 million patients diagnosed with bilateral corneal blindness worldwide. Corneal transplantation is highly successful in low-risk patients with corneal ...

    • EIT image-based bladder state classification for nocturnal enuresis 

      Dunne, Eoghan; Santorelli, Adam; McGinley, Brian; O'Halloran, Martin; Leader, Geraldine; Porter, Emily (School of Engineering, The University of Edinburgh, 2018-06-11)
      In this paper, we propose the use of electrical impedance tomography (EIT) to support children with nocturnal enuresis. We perform the first image-based threshold classification for determining the bladder state of not ...

    • Immunomodulatory function of licensed human bone marrow mesenchymal stromal cell-derived apoptotic bodies 

      Wang, Jiemin; Donohoe, Ellen; Canning, Aoife; Moosavizadeh, Seyedmohammad; Buckley, Fiona; Brennan, Meadhbh Á.; Ryan, Aideen E.; Ritter, Thomas (Elsevier, 2023-10-23)
      Background Mesenchymal stromal cells (MSCs) show great potential for immunomodulatory and anti-inflammatory treatments. Clinical trials have been performed for the treatment of Type 1 diabetes, graft-versus-host disease ...

    • Integrated analyses of microbiome and longitudinal metabolome data reveal microbial-host interactions on sulfur metabolism in Parkinson's disease. 

      Hertel, Johannes; Harms, Amy C.; Heinken, Almut; Baldini, Federico; Thinnes, Cyrille C; Glaab, Enrico; Vasco, Daniel A.; Pietzner, Maik; Stewart, Isobel D.; Wareham, Nicholas J.; Langenberg, Claudia; Trenkwalder, Claudia; Krüger, Rejko; Hankemeier, Thomas; Fleming, Ronan M. T.; Mollenhauer, Brit; Thiele, Ines (Elsevier, 2019-11-12)
      Parkinson's disease (PD) exhibits systemic effects on the human metabolism, with emerging roles for the gut microbiome. Here, we integrate longitudinal metabolome data from 30 drug-naive, de novo PD patients and 30 matched ...

    • Integrated in vitro and in silico modelling delineates the molecular effects of a synbiotic regimen on colorectal cancer-derived cells 

      Greenhalgh, Kacy; Ramiro-Garcia, Javier; Heinken, Almut; Ullmann, Pit; Bintener, Tamara; Pires Pacheco, Maria; Baginska, Joanna; Shah, Pranjul; Frachet, Audrey; Halder, Rashi; Fritz, Joëlle V.; Sauter, Thomas; Thiele, Ines; Haan, Serge; Letellier, Elisabeth; Wilmes, Paul (Cell Press, 2019-04-30)
      By modulating the human gut microbiome, prebiotics and probiotics (combinations of which are called synbiotics) may be used to treat diseases such as colorectal cancer (CRC). Methodological limitations have prevented ...

    • A longitudinal survey of antibiotic-resistant enterobacterales in the Irish environment, 2019–2020 

      Hooban, Brigid; Fitzhenry, Kelly; O'Connor, Louise; Miliotis, Georgios; Joyce, Aoife; Chueiri, Alexandra; Farrell, Maeve Louise; DeLappe, Niall; Tuohy, Alma; Cormican, Martin; Morris, Dearbháile (Elsevier, 2022-03-17)
      The natural environment represents a complex reservoir of antibiotic-resistant bacteria as a consequence of different wastewater discharges including anthropogenic and agricultural. Therefore, the aim of this study was to ...

    • Subconjunctival administration of low-dose murine allogeneic mesenchymal stromal cells promotes corneal allograft survival in mice 

      Treacy, Oliver; Lynch, Kevin; Murphy, Nick; Chen, Xizhe; Donohoe, Ellen; Canning, Aoife; Lohan, Paul; Shaw, Georgina; Fahy, Gerry; Ryan, Aideen E.; Ritter, Thomas (BMC, 2021-04-06)
      Systemic administration of mesenchymal stromal cells (MSCs) has been efficacious in many inflammatory disease settings; however, little data are available on the potential immunomodulatory effects following local MSC ...

    • Third-party allogeneic mesenchymal stromal cells prevent rejection in a pre-sensitized high-risk model of corneal transplantation 

      Lohan, Paul; Murphy, Nick; Treacy, Oliver; Lynch, Kevin; Morcos, Maurice; Bingling, Chen; Ryan, Aideen E.; Griffin, Matthew D.; Ritter, Thomas (Frontiers Media, 2018-11-20)
      High-risk cornea transplant recipients represent a patient population with significant un-met medical need for more effective therapies to prevent immunological graft rejection due to heightened anti-donor immune response. ...