Integrated analyses of microbiome and longitudinal metabolome data reveal microbial-host interactions on sulfur metabolism in Parkinson's disease.
Harms, Amy C.
Thinnes, Cyrille C
Vasco, Daniel A.
Stewart, Isobel D.
Wareham, Nicholas J.
Fleming, Ronan M. T.
MetadataShow full item record
This item's downloads: 263 (view details)
Cited 17 times in Scopus (view citations)
Hertel, Johannes, Harms, Amy C., Heinken, Almut, Baldini, Federico, Thinnes, Cyrille C., Glaab, Enrico, Vasco, Daniel A., Pietzner, Maik, Stewart, Isobel D.,Wareham, Nicholas J.,Langenberg, Claudia, Trenkwalder, Claudia, Krüger, Rejko, Hankemeier, Thomas, Fleming, Ronan M. T., Mollenhauer, Brit, Thiele, Ines. (2019). Integrated Analyses of Microbiome and Longitudinal Metabolome Data Reveal Microbial-Host Interactions on Sulfur Metabolism in Parkinson’s Disease. Cell Reports, 29(7), 1767-1777.e1768. doi: https://doi.org/10.1016/j.celrep.2019.10.035
Parkinson's disease (PD) exhibits systemic effects on the human metabolism, with emerging roles for the gut microbiome. Here, we integrate longitudinal metabolome data from 30 drug-naive, de novo PD patients and 30 matched controls with constraint-based modeling of gut microbial communities derived from an independent, drug-naive PD cohort, and prospective data from the general population. Our key results are (1) longitudinal trajectory of metabolites associated with the interconversion of methionine and cysteine via cystathionine differed between PD patients and controls; (2) dopaminergic medication showed strong lipidomic signatures; (3) taurine-conjugated bile acids correlated with the severity of motor symptoms, while low levels of sulfated taurolithocholate were associated with PD incidence in the general population; and (4) computational modeling predicted changes in sulfur metabolism, driven by A. muciniphila and B. wadsworthia, which is consistent with the changed metabolome. The multi-omics integration reveals PD-specific patterns in microbial-host sulfur co-metabolism that may contribute to PD severity.
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland
Showing items related by title, author, creator and subject.
Analysis of short-term metabolic alterations in arabidopsis following changes in the prevailing environmental conditions Florian, Alexandra; Nikoloski, Zoran; Sulpice, Ronan; Timm, Stefan; Araújo, Wagner L.; Tohge, Takayuki; Bauwe, Hermann; Fernie, Alisdair R. (Elsevier BV, 2014-05-01)Although a considerable increase in our knowledge concerning the importance of metabolic adjustments to unfavorable growth conditions has been recently provided, relatively little is known about the adjustments which occur ...
Spatially resolved metabolic analysis reveals a central role for transcriptional control in carbon allocation to wood Roach, Melissa; Arrivault, Stéphanie; Mahboubi, Amir; Krohn, Nicole; Sulpice, Ronan; Stitt, Mark; Niittylä, Totte (Oxford University Press (OUP), 2017-06-22)The contribution of transcriptional and post-transcriptional regulation to modifying carbon allocation to developing wood of trees is not well defined. To clarify the role of transcriptional regulation, the enzyme activity ...
Negative energy balance and hepatic gene expression patterns in high-yielding dairy cows during the early postpartum period: a global approach McCarthy, S. D.; Waters, S. M.; Kenny, D. A.; Diskin, M. G.; Fitzpatrick, R.; Patton, J.; Wathes, D. C.; Morris, D. G. (American Physiological Society, 2010-08-17)McCarthy SD, Waters SM, Kenny DA, Diskin MG, Fitzpatrick R, Patton J, Wathes DC, Morris DG. Negative energy balance and hepatic gene expression patterns in high-yielding dairy cows during the early postpartum period: a ...